Two reentrant pathways in the hippocampal-entorhinal system

Hippocampus
Fabian KloostermanFernando H Lopes da Silva

Abstract

The entorhinal cortex has long been recognized as an important interface between the hippocampal formation and the neocortex. The notion of bidirectional connections between the entorhinal cortex and the hippocampal formation have led to the suggestion that hippocampal output originating in CA1 and subiculum may reenter hippocampal subfields via the entorhinal cortex. To investigate this, we used simultaneous multi-site field potential recordings and current source density analysis in the entorhinal cortex and hippocampal formation of the rat in vivo. Under ketamine/xylazine anesthesia, we found that repetitive stimulation of subiculum or Schaffer collaterals facilitated entorhinal responses, such that a population spike appeared in layer III. In addition, a current sink in stratum lacunosum-moleculare of area CA1 was found, that followed responses in the entorhinal cortex, indicating reentrance into this area. Responses indicating reentrance in the dentate gyrus were not found under ketamine/xylazine anesthesia, but were readily evoked under urethane anesthesia. Reentrance into CA1 was also encountered under urethane anesthesia. These results suggest that parallel, but possibly functionally distinct, connections are present be...Continue Reading

References

Mar 1, 1975·Journal of Neurophysiology·J A Freeman, C Nicholson
Oct 1, 1976·The Journal of Comparative Neurology·O Steward, S A Scoville
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M F Yeckel, T W Berger
Feb 7, 1998·Journal of Neurophysiology·T GloveliU Heinemann
Aug 13, 1998·The Journal of Comparative Neurology·R D Burwell, D G Amaral
Aug 14, 1998·The Journal of Comparative Neurology·C L Dolorfo, D G Amaral
Mar 11, 2000·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·J M Fuster
Jul 27, 2000·Annals of the New York Academy of Sciences·A Lörincz, G Buzsáki
Jul 27, 2000·Annals of the New York Academy of Sciences·P A NaberF H Lopes Silva
Jul 31, 2001·Trends in Neurosciences·X J Wang
Sep 13, 2002·Journal of Computational Neuroscience·András LorinczGábor Szirtes
Nov 28, 2002·The Journal of Comparative Neurology·Fabian KloostermanTheo Van Haeften
Apr 18, 2003·Hippocampus·Renata Bartesaghi, Tiziana Gessi

❮ Previous
Next ❯

Citations

May 9, 2007·Nature Neuroscience·Caswell BarryKathryn J Jeffery
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Caswell BarryNeil Burgess
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sarah StewartColin Lever
Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Colin LeverNeil Burgess
Aug 20, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pascale QuilichiniGyörgy Buzsáki
Aug 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steve M KimLoren M Frank
Sep 28, 2014·Journal of Computational Neuroscience·Roman A SandlerVasilis Z Marmarelis
Oct 7, 2014·Journal of Computational Neuroscience·Filippo Cona, Mauro Ursino
Mar 23, 2011·Progress in Neurobiology·John Kealy, Sean Commins
Nov 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Juan F Ramirez-VillegasMichel Besserve
Oct 4, 2006·Hippocampus·Liset Menendez de la PridaRichard Miles
Dec 13, 2006·The Journal of Comparative Neurology·James J Chrobak, David G Amaral
Jul 5, 2008·The European Journal of Neuroscience·Nikolay A Vorobyov, Malcolm W Brown
Jun 29, 2007·Hippocampus·Neil BurgessJohn O'Keefe
Jan 3, 2006·Experimental Neurology·Justin C SanchezPaul R Carney
Feb 12, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Witold J Lipski, Anthony A Grace
Aug 28, 2009·Neuron·Thomas J DavidsonMatthew A Wilson
Sep 5, 2008·Neural Plasticity·Cathrin B CantoMenno P Witter
Jun 19, 2016·Trends in Cognitive Sciences·Dharshan KumaranJames L McClelland
Jul 25, 2018·Epilepsia·Patrizia AracriLaura Uva
Jun 12, 2010·Journal of Neurophysiology·Arjun V SharmaClayton T Dickson
Sep 12, 2015·Journal of Neural Engineering·Roman A SandlerVasilis Z Marmarelis
Dec 17, 2009·Neuroscience and Behavioral Physiology·I G Sil'kis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.