Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists

Pharmacology, Biochemistry, and Behavior
Julieta Troncoso, H Maldonado

Abstract

A visual danger stimulus (VDS) elicits an escape response in the crab Chasmagnathus that declines after a few iterative presentations. Long-lasting retention of such decrement, termed context-signal memory (CSM), is mediated by an association between danger stimulus and environmental cues, cycloheximide sensitive, correlated with PKA activity and NFkappa-B activation, positively modulated by angiotensins, and selectively regulated by a muscarinic-cholinergic mechanism. The present research was aimed at studying the possible involvement of NMDA-like receptors in CSM, given the role attributed to these receptors in vertebrate memory and their occurrence in invertebrates including crustaceans. Vertebrate antagonists (+/-)-2-amino-5-phosphonopentanoic acid (AP5) and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) were used. Memory retention impairment was shown with MK-801 10(-3) M (1 microg/g) injected immediately before training or after training, or delayed 1 or 4 h, but not 6 h, posttraining. An AP5 10(-3) M dose (0.6 microg/g) impairs retention when given before but not after training. Neither antagonist produced retrieval deficit. A memory process similar to CSM but nonassociative in nature and induc...Continue Reading

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Citations

Dec 19, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·María del Valle FathalaHéctor Maldonado
Oct 7, 2004·Learning & Memory·María Eugenia PedreiraHéctor Maldonado
Sep 11, 2010·Neurobiology of Learning and Memory·Lia FrenkelAlejandro Delorenzi
Feb 3, 2009·Neurobiology of Learning and Memory·Daniel TomsicHector Maldonado
Mar 19, 2016·Neurobiology of Learning and Memory·F J MazaA Delorenzi
Dec 15, 2012·The Journal of Comparative Neurology·Yanil HeppRamiro A M Freudenthal
Sep 16, 2006·Neurobiology of Learning and Memory·Laura KaczerHéctor Maldonado
Jun 24, 2003·Neuron·María Eugenia Pedreira, Héctor Maldonado
Feb 21, 2004·Nature Reviews. Neuroscience·Federico Bermúdez-Rattoni
Feb 3, 2007·Learning & Memory·Luis María Pérez-CuestaHéctor Maldonado

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