Two rheologically different gastric mucus secretions with different putative functions

Biochimica Et Biophysica Acta
Catherine TaylorJeffrey P Pearson

Abstract

Previous work has shown the presence of different mucin gene products and glycosylated species in gastric mucus secretions, however, the functional relevance of these differences is unclear. This study aimed to investigate rheologically, differences in the gel behaviour within gastric mucus samples using a pig model. Rheological measurements were made on a Bohlin CVO50 rheometer. Mucins were characterised by antigenicity, lectin reactivity and proteolytic fragmentation patterns. Two distinct mucus gel secretions, one compliant with and the other resistant to shear stress, were removed from the gastric mucosa. The two gels had different rheological behaviour profiles and exhibited structural differences in their constituent mucins. The shear-compliant mucus was located superficially to the adherent shear-resistant mucus layer and was shown not to be a proteolytic product of the latter. This study has demonstrated that there are two rheologically distinct mucus gel secretions with structural/compositional differences in the stomach. Rheological properties suggest that the adherent, shear-resistant gel could provide the mucus barrier in vivo while the shear-compliant gel could act primarily as a lubricant.

Citations

Dec 15, 2010·International Journal of Inflammation·Jeffrey P Pearson, Iain A Brownlee
Jan 27, 2009·Advanced Drug Delivery Reviews·Samuel K LaiJustin Hanes
Aug 15, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sejin OhSalvador Borrós
Mar 12, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M D WilcoxJ P Pearson
Nov 3, 2006·Mathematical Biosciences·Muraari Vasudevan, Carlos F Lange
Feb 11, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Irene Pereira de SousaAndreas Bernkop-Schnürch
Feb 11, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Muthanna AbdulkarimMark Gumbleton
Apr 2, 2011·Research in Veterinary Science·Alan D PembertonJeffrey P Pearson
Jun 18, 2016·International Journal of Pharmaceutics·Harish BokkasamClaus-Michael Lehr
Feb 13, 2016·Microbiology and Molecular Biology Reviews : MMBR·Desirée C YangNina R Salama
Sep 15, 2005·The British Journal of Sociology·Richard Ericson
Jan 18, 2006·Nursing Philosophy : an International Journal for Healthcare Professionals·Brenda L Cameron
Dec 14, 2004·American Journal of Physiology. Cell Physiology·Adrian Allen, Gunnar Flemström

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