PMID: 9557665Apr 29, 1998Paper

Two RING finger proteins, the oncoprotein PML and the arenavirus Z protein, colocalize with the nuclear fraction of the ribosomal P proteins

Journal of Virology
Katherine L B BordenMaria S Salvato

Abstract

The promyelocytic leukemia (PML) protein forms nuclear bodies which are relocated to the cytoplasm by the RNA virus lymphocytic choriomeningitis virus (LCMV). The viral Z protein directly binds to PML and can relocate the nuclear bodies. Others have observed that LCMV virions may contain ribosomes; hence, we investigated the effects of infection on the distribution of ribosomal P proteins (P0, P1, and P2) with PML as a reference point. We demonstrate an association of PML bodies with P proteins by indirect immunofluorescence and coimmunoprecipitation experiments, providing the first evidence of nucleic acid-binding proteins associated with PML bodies. We show that unlike PML, the P proteins are not redistributed upon infection. Immunofluorescence and coimmunoprecipitation studies indicate that the viral Z protein binds the nuclear, but not the cytoplasmic, fraction of P0. The nuclear fraction of P0 has been associated with translationally coupled DNA excision repair and with nonspecific endonuclease activity; thus, P0 may be involved in nucleic acid processing activities necessary for LCMV replication. During the infection process, PML, P1, and P2 are downregulated but P0 remains unchanged. Further, P0 is present in virions whi...Continue Reading

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Citations

Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alex KentsisKatherine L B Borden
Nov 29, 2007·Cellular Microbiology·Johanna P LaakkonenMaija Vihinen-Ranta
Jul 24, 2010·Journal of Biomedicine & Biotechnology·S E GoñiM E Lozano
Oct 1, 2011·Journal of Virology·Maria Eugenia LoureiroNora Lopez
Dec 4, 2012·Viruses·Sarah Katharina FehlingThomas Strecker
Feb 26, 2013·Viruses·Svenja WolffAllison Groseth
Feb 26, 2016·Journal of Virology·Kathryn M HastieErica Ollmann Saphire
Sep 13, 2003·Journal of Virology·Rodrigo JácamoMaría T Franze-Fernández
Jul 9, 2004·Scandinavian Journal of Immunology·E ErsvaerB T Gjertsen
Jan 25, 2013·Viruses·Juan C Zapata, Maria S Salvato
Jul 19, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Christopher H Eskiw, David P Bazett-Jones
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May 1, 2008·Annual Review of Plant Biology·Franziska TurckGeorge Coupland
Dec 20, 2007·The Journal of General Virology·Richard E Randall, Stephen Goodbourn
Oct 19, 2004·Critical Reviews in Clinical Laboratory Sciences·Stephan Günther, Oliver Lenz
Apr 20, 2011·Cellular Microbiology·H Zakaryan, T Stamminger
Sep 10, 2010·Journal of Virology·Bouchra El McHichiMounira K Chelbi-Alix
Jan 25, 2013·Viruses·Magali E Droniou-Bonzom, Paula M Cannon
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Nov 13, 2001·Oncogene·K JensenP S Freemont
Nov 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alex KentsisKatherine L B Borden
Aug 13, 2010·Journal of Virology·Danielle BlondelMounira K Chelbi-Alix
Feb 2, 2000·Journal of Molecular Biology·K L Borden
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