May 24, 2020

Two Sides to the Same Coin-Cytotoxicity vs. Potential Metastatic Activity of AgNPs Relative to Triple-Negative Human Breast Cancer MDA-MB-436 Cells

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Magdalena Matysiak-KucharekLucyna Kapka-Skrzypczak

Abstract

Silver nanoparticles (AgNPs) are used in many fields of industry and medicine. Despite the well-established antimicrobial activity, AgNPs are foreseen to be used as anticancer drugs due to the unusual feature-inability to induce drug resistance in cancer cells. The aim of the study was to assess biological activity of AgNPs against MDA-MB-436 cells. The cells were derived from triple-negative breast cancer, a type of breast cancer with poor prognosis and is particularly difficult to cure. AgNPs were toxic to MDA-MB-436 cells and the probable mechanism of toxicity was the induction of oxidative stress. These promising effects, giving the opportunity to use AgNPs as an anti-cancer agent should, however, be treated with caution in the light of further results. Namely, the treatment of MDA-MB-436 cells with AgNPs was associated with the increased secretion of several cytokines and chemokines, which were important in breast cancer metastasis. Finally, changes in the actin cytoskeleton of MDA-MB-436 cells under the influence of AgNPs treatment were also observed.

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Mentioned in this Paper

Oxidative Stress
3,4-Methylenedioxyamphetamine
Tumor Cells, Malignant
Silver
Chemokine
Cytotoxicity
Malignant Neoplasm of Breast
Cytokine
Triple Negative Breast Neoplasms
Prognosis Bad

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