Two spectral types of retinal light damage occur in albino as well as in pigmented rat: no essential role for melanin

Experimental Eye Research
T G Gorgels, D van Norren

Abstract

Earlier we showed that two spectral types of retinal damage occur in the pigmented rat. In the present study we investigated whether the same is true for albino rats. When investigating this issue we implicitly investigated the role of melanin in both damage types. An albinotic (Wistar) and a pigmented (Long Evans) strain of rats were used. Under anesthesia, a small part of the retina was irradiated at either 380 nm or at 470 nm. Three days later, the retina was analysed by funduscopy and prepared for light microscopy. Funduscopy showed no signs of damage in the albinotic retina. In the pigmented retina a decoloration of the fundus was noticed after irradiations starting from retinal doses of 0.6+/-0.1 J cm-2 at 380 nm, and from 489+/-71 J cm-2 at 470 nm. By light microscopy, retinal damage was found in the albino retina. The histologic manifestations at 380 nm differed from those at 470 nm. Irradiation at 380 nm at a dose of 0. 5-0.9 J cm-2 damaged a few scattered photoreceptor cells. At doses of 1.2-1.6 J cm-2 all rods were damaged, while the other retinal layers showed no changes. These findings were similar to those found at 380 nm in the pigmented rat. At 470 nm, damage was found most prominently in the retinal pigment epi...Continue Reading

References

Feb 1, 1992·Photochemistry and Photobiology·R D Glickman, K W Lam
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Citations

Aug 24, 1999·Pigment Cell Research·U Schraermeyer, K Heimann
May 23, 2006·The British Journal of Ophthalmology·M A Mainster
Dec 9, 2003·The British Journal of Ophthalmology·M A Mainster, J R Sparrow
Nov 26, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hans Peter IseliMike Francke
May 24, 2011·Progress in Retinal and Eye Research·F Behar-CohenD Attia
Mar 18, 2011·Photochemistry and Photobiology·Dirk van Norren, Theo G M F Gorgels
Sep 5, 2006·Survey of Ophthalmology·Jiangmei WuPeep V Algvere
Jul 26, 2015·Experimental Eye Research·Hans Peter IseliMike Francke
Jul 6, 2014·Oxidative Medicine and Cellular Longevity·Manuel Saenz-de-ViteriAlfredo García-Layana
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Oct 3, 2006·Japanese Journal of Ophthalmology·Jun AraiNagahisa Yoshimura

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