PMID: 8959373Jan 1, 1996Paper

Two-stage gene regulation of the superoxide stress response soxRS system in Escherichia coli

Critical Reviews in Eukaryotic Gene Expression
T Nunoshiba

Abstract

All organisms have adapted to environmental changes by acquiring various functions controlled by gene regulation. In bacteria, a number of specific responses have been found to confer cell survival in various nutrient-limited conditions, and under physiological stresses such as high or low temperature, extreme pH, radiation, and oxidation (for review, see Neidhardt et al., 1987). In this article, I introduce an Escherichia coli (E. coli) global response induced by superoxide stress, the soxRS regulon. The functions controlled by this system consist of a wide variety of enzymes such as manganese-containing SOD (Mn-SOD); glucose 6-phosphate dehydrogenase (G6PD), the DNA repair enzyme endonuclease IV, fumarase C, NADPH:ferredoxin oxidoreductase, and aconitase. This response is positively regulated by a two-stage control system in which SoxR iron-sulfur protein senses exposure to superoxide and nitric oxide, and then activates transcription of the soxS gene, whose product stimulates the expression of the regulon genes. Our recent finding indicates that soxS transcription is initiated in a manner dependent on the rpoS gene encoding RNA polymerase sigma factor, theta s, in response to entering the stationary phase of growth. With thi...Continue Reading

Citations

Nov 6, 2002·Journal of Molecular Biology·Nitzan RosenfeldUri Alon
Jan 1, 1996·Free Radical Biology & Medicine·A EisenstarkA Ivanova
Sep 4, 2003·The Journal of Experimental Medicine·Martin I VoskuilGary K Schoolnik
Sep 1, 2009·Journal of Bacteriology·Sankaralingam SaikolappanSubramanian Dhandayuthapani
Jan 1, 1997·Annual Review of Biochemistry·S M UptainM J Chamberlin
Jan 19, 1999·Annual Review of Microbiology·K T Hughes, K Mathee
Jul 5, 2012·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Irwin Fridovich
Sep 6, 2000·European Journal of Biochemistry·H Beinert
Sep 19, 2002·Protein Science : a Publication of the Protein Society·Gaoping XiaoChi-Hong B Chen
May 8, 2002·Molecular Microbiology·Sally-J RowlandMartin R Boocock
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Susan Gottesman
Feb 27, 2001·Biomolecular Engineering·N StojćevićM Konstantinović
Jul 27, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jeffrey S ArmstrongDean P Jones
Sep 15, 2007·Electrophoresis·Daniel FologeaJiali Li
Dec 5, 2012·Molecular Microbiology·Rebecca SheplockMonica Chander
Jul 13, 2004·Journal of Photochemistry and Photobiology. B, Biology·Karina I Dantur, Ramón A Pizarro
Jan 19, 2006·Journal of Microbiological Methods·Dwayne A EliasMary S Lipton
Sep 7, 2005·Metabolic Engineering·Steven J CoxKa-Yiu San
Mar 1, 2012·Journal of Molecular Biology·Paula VivasAnjum Ansari
Apr 1, 1997·Current Biology : CB·A Travers
May 18, 1999·Archives of Biochemistry and Biophysics·J ThongphasukT D Oberley
Mar 1, 1997·Methods : a Companion to Methods in Enzymology·B Demple
Aug 3, 1999·Nature Biotechnology·M A Matzke, A J Matzke
Jun 22, 2017·Scientific Reports·Omar A GarnicaSubramanian Dhandayuthapani
Jun 8, 2002·Archives of Biochemistry and Biophysics·Ludmil BenovIrwin Fridovich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.