Two stomach-originated Lactobacillus strains improve Helicobacter pylori infected murine gastritis.

World Journal of Gastroenterology : WJG
Yi CuiFang-Gen Lu

Abstract

To investigate the potential anti-Helicobacter pylori (H. pylori) and anti-inflammation in vivo effects of two lactobacillus strains from human stomach. Forty H. pylori infected Balb/c mice were randomly divided into 4 groups: proton pump inhibitor and antibiotics triple treated group, Lactobacillus fermenti (L. fermenti) treated group, Lactobacillus acidophilus treated group and normal saline control group. Ten uninfected mice were also included as blank control group. The infection of H. pylori was detected by rapid urease tests, Giemsa staining and bacterial culture. The colonization of H. pylori was assessed in bacterial density score and gastric inflammation was assessed in histological score. The colonization of L. fermenti was performed by fluorescent probe. Histopathologic evaluation showed significant release of mucosal inflammation in gastric antrum and gastric body in lactobacillus treated groups and triple treated group. H. pylori eradication rate in both lactobacillus treated groups and triple treated group were higher than normal saline control group. Lactobacillus treated groups and triple treated group showed significant decrease of H. pylori bacterial density. Both lactobacillus strains have a significant anti-...Continue Reading

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Citations

Aug 20, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Julia M SchmitzRobin G Lorenz
Mar 30, 2011·Journal of the Science of Food and Agriculture·Wen-Hsin LinHsin-Ling Yang
Feb 14, 2012·FEMS Microbiology Ecology·Jose F Garcia-MazcorroOlivier Dossin
Oct 14, 2014·World Journal of Gastroenterology : WJG·Francesco RussoAntonella Orlando

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