Two swine models of iliac vein occlusion: Which form most contributes to venous thrombosis?

Thrombosis Research
Wan-Yin ShiJian-Ping Gu

Abstract

In the present study, we establish two swine models of iliac vein occlusion (IVO) with spontaneous thrombosis to understand the mechanisms linking IVO and thrombosis. Two IVO models were established in 12 swine either by ligating the common iliac vein (CIVO) or both the common and external iliac veins (CEIVO). Venography was performed to assess each model and the associated thrombosis. Invasive blood pressure was also measured, and the vessels were examined histologically to analyse the pathological changes after ligation. On venography, the CIVO model showed common iliac vein (CIV) occlusion and reflux in the collateral veins whereas the CEIVO model showed occlusion in the CIV and external iliac vein (EIV), stasis in the EIV, and decreased collateral vasculature on venography. Thrombosis was only observed in the CEIVO model, which was with significantly higher venous blood pressure in the EIV and with significantly more thickened venous wall with lymphocytic infiltration histologically. Two IVO models can be feasibly and reliably established in swine. The CEIVO model had a higher prevalence of thrombosis than the CIVO model. This CEIVO model produces comparatively less collateral drainage and greater inflammation that can cont...Continue Reading

References

May 1, 1996·Journal of Vascular and Interventional Radiology : JVIR·J HosakaF Laerum
Aug 4, 1998·Cardiovascular and Interventional Radiology·S RoyK S Sakariassen
Feb 9, 2000·Journal of Vascular Surgery·T W WakefieldL J Greenfield
Feb 8, 2003·Hypertension·Richard A PrestonYeon S Ahn
Mar 19, 2004·Journal of Vascular and Interventional Radiology : JVIR·Jin Wook ChungJae Hyung Park
Apr 28, 2004·Journal of Vascular Surgery·Melina R KibbeJon Matsumura
Jun 21, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·B GeierA Mumme
Feb 26, 2008·Journal of Vascular and Interventional Radiology : JVIR·Levent OguzkurtFahri Tercan
Aug 1, 2009·Blood·Sandra J HasstedtEdwin G Bovill
Aug 10, 2010·Annual Review of Physiology·David A ManlyNigel Mackman
Feb 1, 2011·Journal of Vascular and Interventional Radiology : JVIR·Keith T ChanLawrence V Hofmann
Apr 5, 2013·Journal of Biomedical Materials Research. Part a·Alexandra E JantzenGeorge A Truskey
Jan 1, 2012·Annals of Vascular Diseases·Wael IbrahimWael Abu Zeid
Sep 10, 2013·Thrombosis Research·Constantine N AntonopoulosChristos D Liapis
Mar 19, 2014·Cardiovascular and Interventional Radiology·Andreas H MahnkenGerard J O'Sullivan

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Citations

May 4, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Adeline SchweinJean Bismuth

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