Two-tone distortion on the basilar membrane of the chinchilla cochlea

Journal of Neurophysiology
L RoblesN C Rich

Abstract

Basilar membrane responses to pairs of tones were measured, with the use of a laser velocimeter, in the basal turn of the cochlea in anesthetized chinchillas. Frequency spectra of basilar membrane responses to primary tones with frequencies (f1, f2) close to the characteristic frequency (CF) contain prominent odd-order two-tone distortion products (DPs) at frequencies both higher and lower than CF (such as 2f1-f2, 3f1-2f3, 2f2-f1 and 3f2-2f1). For equal-level primaries with frequencies such that 2f1-f2 equals CF, the magnitude of the 2f1-f2 DP grows with primary level at linear or faster rates at low stimulus levels, but it saturates or decreases slightly at higher levels. For a fixed level of one of the primary tones, the magnitude of the 2f1-f2 DP is a nonmonotonic function of the level of the other primary tone. For low intensities of the variable tone, the 2f1-f2 DP grows at a rate of approximately 2 dB/dB with f1 level and 1 dB/dB with f2 level. DP magnitudes decrease rapidly with increasing primary frequency ratio (f2/f1) at low stimulus levels. For more intense stimuli, DP magnitudes remain constant or decrease slowly over a wide range of frequency ratios until a critical value is reached, at which DP magnitudes fall wit...Continue Reading

References

Jun 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A J Hudspeth, D P Corey
Aug 10, 1979·Science·P M Zurek, R M Sachs
Sep 1, 1978·The Journal of the Acoustical Society of America·T J Buunen, W S Rhode
Jan 1, 1975·The Journal of the Acoustical Society of America·R Weber, V Mellert
Nov 1, 1975·The Journal of the Acoustical Society of America·J L Hall
Apr 1, 1976·The Journal of the Acoustical Society of America·G F SmoorenburgJ E Hind
Oct 22, 1992·Proceedings. Biological Sciences·A M BrownD M Williams
Dec 22, 1992·Proceedings. Biological Sciences·I J RussellG P Richardson
May 1, 1991·The Journal of the Acoustical Society of America·R ProbstG K Martin
Feb 1, 1990·The Journal of the Acoustical Society of America·A L Nuttall, D F Dolan
Jun 1, 1990·The Journal of the Acoustical Society of America·E Zwicker, F P Harris
Oct 1, 1989·Hearing Research·R B PatuzziB M Johnstone
Jan 1, 1989·The Journal of the Acoustical Society of America·F P HarrisG K Martin
Jul 1, 1988·The Journal of the Acoustical Society of America·M FurstP M Zurek
Jan 11, 1985·Science·W E BrownellY de Ribaupierre
Jan 19, 1973·Nature·J P Wilson, J R Johnstone
Apr 1, 1971·The Journal of the Acoustical Society of America·W S Rhode
Mar 1, 1967·The Journal of the Acoustical Society of America·J L Goldstein
Jan 1, 1983·Hearing Research·H Davis
Feb 1, 1982·Journal of Neurophysiology·J H SiegelC E Molnar
Jul 1, 1982·The Journal of the Acoustical Society of America·P M SellickB M Johnstone
Sep 1, 1981·The Journal of the Acoustical Society of America·A R Cody, B M Johnstone
Jul 1, 1980·Hearing Research·A R Cody, B M Johnstone
Nov 1, 1993·Biophysical Journal·J Santos-Sacchi
Aug 5, 1993·Nature·F JaramilloA J Hudspeth
Apr 1, 1993·The Journal of the Acoustical Society of America·A L Nuttall, D F Dolan

❮ Previous
Next ❯

Citations

Dec 7, 2000·The Journal of the Acoustical Society of America·A Recio, W S Rhode
Aug 4, 2007·The Journal of the Acoustical Society of America·David W PurcellChristo Pantev
Apr 6, 2007·The Journal of the Acoustical Society of America·Christopher A SheraJohn J Guinan
Oct 14, 2008·Nature·Elisabeth VerpyChristine Petit
Jun 12, 2010·Journal of Neurophysiology·A J HudspethPascal Martin
Sep 28, 2010·Journal of the Association for Research in Otolaryngology : JARO·William P Shofner
Oct 19, 2013·Physiological Reviews·Paul AvanChristine Petit
Aug 22, 2015·BioMed Research International·Michio MurakoshiHiroshi Wada
May 28, 2016·Journal of the Association for Research in Otolaryngology : JARO·Glen K MartinBrenda L Lonsbury-Martin
Dec 3, 2016·Journal of the Association for Research in Otolaryngology : JARO·Wei Dong
Oct 12, 2018·Nature Communications·Alfred L NuttallAnders Fridberger
Dec 5, 2019·The Journal of the Acoustical Society of America·Monica TrevinoMichael G Heinz
Jan 5, 2002·The Journal of the Acoustical Society of America·L E Dreisbach, J H Siegel
Aug 1, 1997·The Journal of the Acoustical Society of America·M A Cheatham, P Dallos
Aug 21, 2004·The Journal of Physiology·M A CheathamP Dallos
Jun 28, 2001·Physiological Reviews·L Robles, M A Ruggero
Apr 6, 2005·The Journal of the Acoustical Society of America·Egbert de BoerJiefu Zheng
Oct 12, 2007·The Journal of the Acoustical Society of America·Lin Bian, Nicole M Scherrer
Aug 2, 2018·Psychonomic Bulletin & Review·I-Hui Hsieh, Jia-Wei Liu
May 5, 1998·The Journal of the Acoustical Society of America·A RecioM A Ruggero
Oct 14, 2004·The Journal of the Acoustical Society of America·M C LibermanJ J Guinan
Apr 29, 2006·The Journal of the Acoustical Society of America·Tianying Ren, Alfred L Nuttall
Aug 11, 2006·Journal of Neurophysiology·Tianying RenAlfred L Nuttall
Jun 25, 2008·International Journal of Audiology·Hala Elsisy, Ananthanarayan Krishnan
Nov 4, 2005·The Journal of the Acoustical Society of America·Ana Alves-Pinto, Enrique A Lopez-Poveda
Nov 30, 2011·The Journal of Physiology·Andrei S KozlovA J Hudspeth
May 17, 2011·The Journal of the Acoustical Society of America·Joyce Rodriguez, Stephen T Neely
Jun 24, 2014·Nature Communications·Tatjana Tchumatchenko, Tobias Reichenbach
Sep 1, 2012·Journal of the Association for Research in Otolaryngology : JARO·Corstiaen P C Versteegh, Marcel van der Heijden
Sep 15, 2012·Annals of the New York Academy of Sciences·Edward W Large, Felix V Almonte
Jul 10, 2014·Reports on Progress in Physics·Tobias Reichenbach, A J Hudspeth
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·F JülicherT Duke
Jul 16, 2005·The Journal of the Acoustical Society of America·Sumitrajit DharArnold Tubis
Jun 17, 2005·The Journal of the Acoustical Society of America·Wei Dong, Elizabeth S Olson
Oct 29, 2000·The Journal of the Acoustical Society of America·P F FaheyG K Martin
May 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jérémie Barral, Pascal Martin
Jan 8, 2008·The Journal of the Acoustical Society of America·W Dong, E S Olson
Nov 28, 2008·Journal of Neurophysiology·Cornelius Abel, Manfred Kössl
Aug 7, 2014·Nature Reviews. Neuroscience·A J Hudspeth
Mar 25, 2011·The Journal of the Acoustical Society of America·Jingyuan Huang, Lori L Holt
Sep 24, 1998·The Journal of the Acoustical Society of America·C L TalmadgeP Piskorski
Mar 23, 2004·Nature Neuroscience·Tianying Ren
Nov 4, 2005·The Journal of the Acoustical Society of America·Jonathan H SiegelMario A Ruggero

❮ Previous
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