PMID: 2496007Jan 1, 1989Paper

Two transcripts from the rotund region of Drosophila show similar positional specificities in imaginal disc tissues

Genes & Development
M AgnelR Griffin-Shea

Abstract

The rotund (rn) mutation in Drosophila is unique in that its phenotype is limited to the deletion of specific distal parts, though not the extremities, of all adult appendages. We have cloned the rn gene, located at cytogenetic position 84D3,4, by chromosomal walking. The functional rn unit, defined genetically by the localization of 13 noncomplementing rn alleles, covers approximately 50 kb of DNA. Despite different developmental profiles, two transcript size classes (1.7 and 5.3 kb) from this region show an indistinguishable pattern of spatial expression in the imaginal discs at the white pupa stage. There is a high correlation between the specificity of the mutant phenotype and the accumulation of transcripts in the presumptive distal regions of the cuticle-forming epithelial cells of the affected discs; it is, in fact, the first gene reported whose expression is localized with respect to the proximo distal-forming axis. For both transcripts, we have also found, uniquely in the wing disc, expression limited to the anterior region of the mesodermally derived epithelial cells, which contribute to the muscles of the thorax.

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Citations

Mar 1, 1996·Insect Biochemistry and Molecular Biology·R J RussellJ G Oakeshott
May 4, 2010·BMC Genomics·Arun SeetharamGary W Stuart
Nov 5, 2005·Developmental Biology·Olga BarminaArtyom Kopp
Sep 1, 1992·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Magali AgnelChristine Vola
Jun 1, 1995·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Satoshi GotoYoshiki Hotta
Feb 1, 1990·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Michael Brand, José A Campos-Ortega
Oct 24, 2003·Development·Jesus M de Celis Ibeas, Sarah J Bray
Apr 13, 2007·Development·Javier Terriente FélixFernando J Díaz-Benjumea
Sep 20, 2008·Developmental Biology·Jose Ignacio Pueyo, Juan Pablo Couso

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