PMID: 9004175Nov 1, 1996Paper

Two types of growth hormone rhythm in boys with constitutional short stature

Journal of Pediatric Endocrinology & Metabolism : JPEM
R KeretZ Laron

Abstract

The relationship between temporal and quantitative changes in pulsatile growth hormone (GH) secretion and growth of constitutionally short children (CSS) was studied in 19 prepubertal boys and 4 with early adrenarche aged 7.8 to 14 years. Continuous plasma GH monitoring was performed at 30 minutes intervals during 24 hours. The data were analysed by single and serial best fit (BFT) cosinor analysis for rhythm parameters and the Pulsar peak detection program for determining pulsatile properties. The pulsatile patterns were expressed in mean GH concentration, area under the curve, mean pulse area and maximal pulse height but not in the number of pulses. Thirteen out of 23 patterns exhibited significant 24-h compatible rhythms. The studied cohort was divided into two groups, those who exhibited the 24-h circadian rhythm (CIR) and those who lacked it (NCIR). Ultradian 2.5-4 h rhythms were observed in all patients. The NCIR children were significantly shorter than the CIR group (p = 0.017). The CIR boys secreted a significantly higher (p = 0.01) amount of GH during the 24-h span, most of which was during sleep. Our data indicate that the magnitude of pulses rather than their number is responsible for the quantitative differences obs...Continue Reading

References

Jan 1, 1992·Hormone Research·J WeillC Ponte
Feb 1, 1992·Endocrinologia Japonica·T HasegawaY Tsuchiya
Mar 1, 1991·The Journal of Clinical Endocrinology and Metabolism·D L DonaldsonW V Moore
Jul 1, 1990·Pediatric Research·J R KerriganA D Rogol
Sep 1, 1989·The Journal of Clinical Endocrinology and Metabolism·P M MarthaR M Blizzard
Jul 1, 1988·Clinical Endocrinology·P C HindmarshC G Brook
Sep 1, 1988·The Journal of Clinical Endocrinology and Metabolism·K Albertsson-Wikland, S Rosberg
Mar 1, 1987·The Journal of Clinical Endocrinology and Metabolism·N MaurasJ D Veldhuis
Mar 1, 1987·The Journal of Pediatrics·G Costin, F R Kaufman
Nov 1, 1972·The Journal of Clinical Endocrinology and Metabolism·J W FinkelsteinL Hellman
Sep 1, 1968·The Journal of Clinical Investigation·Y TakahashiW H Daughaday

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Citations

Jan 19, 2010·The Journal of Clinical Endocrinology and Metabolism·Ian P HughesPeter S W Davies

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