Two types of intrinsic oscillations in neurons of the lateral and basolateral nuclei of the amygdala

Journal of Neurophysiology
H C PapeR B Driesang

Abstract

Intracellular recordings in the guinea pig and cat basolateral amygdaloid (BL) complex maintained as slices in vitro revealed that a subpopulation of neurons (79%) in the lateral (AL) and basolateral (ABl) nuclei generated two types of slow oscillations of the membrane potential upon steady depolarization from resting potential. The cells were of a stellate or pyramidal-like shape and possessed spiny dendrites and an axon leaving the local synaptic environment, and thus presumably represented projection neurons. Similar oscillatory activity was observed in projection neurons of the cat AL nucleus recorded in vivo. Oscillatory activity with a low threshold of activation (low-threshold oscillation, LTO) appeared as rhythmic deflections (amplitudes, 2-6 mV) of the membrane potential positive to -60 mV. Fast Fourier transformation (FFT) demonstrated a range of frequencies of LTOs between 0.5 and 9 Hz, with >80% occurring at 1-3.5 Hz and an average at 2.3 +/- 1.1 Hz. LTOs were more regular after pharmacological blockade of synaptic transmission and were blocked by tetrodotoxin (TTX). Blockade of LTOs and Na+ spikes revealed a second type of oscillatory activity (high-threshold oscillation, HTO) at depolarizations beyond -40 mV, whic...Continue Reading

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Citations

Jan 16, 2003·The Journal of Comparative Neurology·Jay F MullerAlexander J McDonald
Sep 5, 2009·PLoS Computational Biology·Michiel W H RemmeBoris S Gutkin
May 27, 2010·Brain Structure & Function·Alexander Joseph McDonald, Franco Mascagni
Jan 28, 2014·PloS One·Jorge VeraMagdalena Sanhueza
Mar 11, 2018·The Journal of Comparative Neurology·Monika J M Murphy, Ariel Y Deutch
May 2, 2003·Annals of the New York Academy of Sciences·Hans-Christian Pape, Oliver Stork
Jul 5, 2003·Physiological Reviews·P SahJ Power
Jul 15, 2003·Neuroreport·Sebastian PollandtDoris Albrecht
Jun 26, 2007·Neuroreport·Rajeevan T NarayananHans-Christian Pape
Mar 3, 2007·The European Journal of Neuroscience·Csaba SzinyeiHans-Christian Pape
Apr 14, 2019·The Journal of Comparative Neurology·Alexander J McDonald, Franco Mascagni
Feb 8, 2005·The Journal of Physiology·Gilad A JacobsonYosef Yarom
Sep 15, 2005·Hippocampus·Hans-Christian PapeThomas Seidenbecher
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