PMID: 2531194Dec 1, 1989Paper

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones

The Journal of Experimental Medicine
D F FiorentinoT R Mosmann

Abstract

A cytokine synthesis inhibitory factor (CSIF) is secreted by Th2 clones in response to Con A or antigen stimulation, but is absent in supernatants from Con A-induced Th1 clones. CSIF can inhibit the production of IL-2, IL-3, lymphotoxin (LT)/TNF, IFN-gamma, and granulocyte-macrophage CSF (GM-CSF) by Th1 cells responding to antigen and APC, but Th2 cytokine synthesis is not significantly affected. Transforming growth factor beta (TGF-beta) also inhibits IFN-gamma production, although less effectively than CSIF, whereas IL-2 and IL-4 partially antagonize the activity of CSIF. CSIF inhibition of cytokine synthesis is not complete, since early cytokine synthesis (before 8 h) is not significantly affected, whereas later synthesis is strongly inhibited. In the presence of CSIF, IFN-gamma mRNA levels are reduced slightly at 8, and strongly at 12 h after stimulation. Inhibition of cytokine expression by CSIF is not due to a general reduction in Th1 cell viability, since actin mRNA levels were not reduced, and proliferation of antigen-stimulated cells in response to IL-2, was unaffected. Biochemical characterization, mAbs, and recombinant or purified cytokines showed that CSIF is distinct from IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, I...Continue Reading

References

Dec 1, 1979·The Journal of Experimental Medicine·J Watson
Feb 1, 1986·Cellular Immunology·M A GiedlinT R Mosmann
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J B HorowitzC A Janeway
Aug 1, 1988·The Journal of Experimental Medicine·R Fernandez-BotranE S Vitetta
Aug 1, 1987·The Journal of Experimental Medicine·T EspevikM A Palladino
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C UyttenhoveJ Van Snick
Jul 1, 1985·The Journal of Experimental Medicine·J KimK Bottomly
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G NabelH Cantor

❮ Previous
Next ❯

Citations

Apr 21, 2010·Archives of Dermatology·John E HarrisRobert A Lee
May 29, 1996·International Journal of Cancer. Journal International Du Cancer·W DummerE B Bröcker
Sep 17, 1996·International Journal of Cancer. Journal International Du Cancer·K MoriY Tanaka
May 16, 1997·International Journal of Cancer. Journal International Du Cancer·F Y YueG Burg
Feb 1, 1996·Journal of Cellular Physiology·C Q WangD A Lipschitz
May 29, 1998·European Journal of Immunology·T J D'Orazio, J Y Niederkorn
May 29, 1998·European Journal of Immunology·M TakeuchiO Taguchi
Mar 27, 2001·International Journal of Cancer. Journal International Du Cancer·C SpechtH G Pauels
Mar 1, 1996·Arthritis and Rheumatism·P IsomakiJ Punnonen
Sep 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M F Flajnik
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y YamaguchiM Ogawa
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H Tsukamoto
Feb 15, 2011·Inflammatory Bowel Diseases·Alexandra I Thompson, Charlie W Lees
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·A NeunerJ R Fischer
Sep 5, 2002·Journal of Cellular Biochemistry·Gianpaolo PapaccioMichael V G Latronico
Sep 3, 2002·Pediatric Pulmonology·John R CochranGiuseppe N Colasurdo
May 6, 1998·Protein Science : a Publication of the Protein Society·U ReinekeJ Schneider-Mergener
Sep 22, 2007·Bulletin of Mathematical Biology·M A Fishman, A S Perelson
Jan 1, 1995·Rheumatology International·F M CicuttiniJ A Hamilton
Dec 4, 1998·Springer Seminars in Immunopathology·J HermannF M Brennan
Jan 1, 1997·Springer Seminars in Immunopathology·J J Kim, D B Weiner
Jan 1, 1991·Journal of Clinical Immunology·M T Halpern
Jan 1, 1995·Parasitology Research·P K GhoshL Ortiz-Ortiz
Jan 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J K LackiW Müller
Jan 1, 1992·Cancer Immunology, Immunotherapy : CII·M A SalmeronK Itoh
Apr 1, 1995·Cellular and Molecular Neurobiology·P L RadyT K Hughes
Feb 1, 1994·Cellular and Molecular Neurobiology·T K HughesE M Smith
Jul 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M M ChavesJ A Nogueira-Machado
Mar 1, 1995·Biulleten' eksperimental'noĭ biologii i meditsiny·L R PtitsynA N Kurkin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.