Two types of nicotinic acetylcholine receptor channels at slow fibre end-plates of the garter snake.

The Journal of Physiology
V E Dionne

Abstract

1. Two different types of acetylcholine receptor channels can be detected on the post-junctional membrane of slow muscle fibres in garter snakes. Here they are designated T-type and S-type channels. Only T-type channels can also be found at twitch fibre neuromuscular junctions. 2. The physiological properties of slow fibre T-type channels are similar to those of acetylcholine receptor channels in end-plates of twitch fibres in these animals. 3. S-type channels had a smaller conductance than T-type channels (32 vs. 49 pS), but a similar reversal potential near 0 mV. 4. Both S- and T-type channels were found together in most patches of slow fibre end-plate membrane, but some patches displayed just one type or the other. 5. The activity of both S- and T-type channels desensitized in the presence of micromolar concentrations of acetylcholine. S-type channels desensitized less rapidly and less completely than did T-type channels. 6. Desensitized channels of both types recovered and produced bursts of activity, then went silent again. During a burst, channels did not appear to change type. 7. The activation of channels of either type was not correlated with activity in channels of the other type. 8. The open-duration distribution of ...Continue Reading

Citations

Sep 1, 1990·The Journal of Pharmacy and Pharmacology·I KimuraM Kimura
Jul 21, 1998·Annals of the New York Academy of Sciences·H J Kaminski
May 13, 1999·The American Journal of Medicine·K BoonyapisitR L Ruff
Oct 18, 2005·Muscle & Nerve·Benjamin W HughesHenry J Kaminski
Mar 1, 1993·British Journal of Pharmacology·J C Hardwick, R L Parsons
Dec 1, 1990·The American Journal of Physiology·R L Ruff, P Spiegel

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