PMID: 589469Dec 9, 1977

Two types of receptors for alpha-bungarotoxin in the synaptic layers of the pigeon retina

Brain Research
S Yazulla, J Schmidt

Abstract

Pigeon retinae were analyzed for binding [125I]alpha-bungarotoxin (alphaBgt) by radioautographic and biochemical methods. Toxin binding, localized to the outer and inner plexiform layers (OPL and IPL), was inhibited by micromolar concentrations of native alphaBgt and D-tubocurarine and by 1 mM acetyl- and butyrylcholine in both synaptic layers. Nicotine, at comparable concentrations affected only the IPL. In vitro drug competition experiments showed that the pigeon retina contains two types of receptors for alphaBgt which differ in sensitivity to inhibition by nicotine by 4 orders of magnitued. The results suggest that: (1) the receptor for alphaBgt in the IPL is a nicotinic receptor, (2) the receptor for alphaBgt in the OPL may be involved in an unusual cholinergic system, and (3) ability to bind alphaBgt is not a sufficient criterion for identifying nicotinic-cholinergic receptors.

References

Mar 1, 1976·Journal of Neurochemistry·C D Ross, D B McDougal
Oct 15, 1976·The Journal of Comparative Neurology·A W Spira
Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·Z Vogel, M Nirenberg
Jan 1, 1972·Annual Review of Biochemistry·Z W Hall
Sep 5, 1974·Biochimica Et Biophysica Acta·V A Eterović, E L Bennett
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H C Fertuck, M M Salpeter
Dec 19, 1973·Biochemical and Biophysical Research Communications·P M Salvaterra, W J Moore
May 28, 1953·The Journal of Physiology·C M FRANCIS

Citations

Mar 5, 1979·Life Sciences·B J MorleyP M Salvaterra
Jan 1, 1980·Neuroscience·D A GodfreyF M Matschinsky
Jul 1, 1987·Experimental Eye Research·J B Hutchins
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·N BrechaC Laverack
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J ChesterH G Mautner
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L W SwansonW M Cowan
Jan 1, 1985·Journal of Ocular Pharmacology·B V Sastry
Jan 1, 1986·Journal of Neuroscience Research·P SalazarH Pasantes-Morales
Jan 1, 1982·Medicinal Research Reviews·M D Aceto, B R Martin
Aug 28, 2018·Journal of Clinical Imaging Science·Leslie E HirsigDhanashree A Rajderkar
Jun 1, 1981·European Journal of Biochemistry·H Betz

Related Concepts

kappa-Bungarotoxin
Dose-Response Relationship, Drug
Columba livia
Pigment Epithelium of Eye
Cholinergic Receptors
Nicotinic Receptors
Retina

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