Two Unanticipated Pregnancies While on Cystic Fibrosis Gene-Specific Drug Therapy

Journal of Patient Experience
Sigrid LadoresJanet Brown

Abstract

Women with cystic fibrosis (CF) desire to become pregnant and accomplish the same life goals as women without CF. The underlying pathology of CF and medications used to treat this genetically transmitted disease can affect women's reproductive potential. An interview with Ana (pseudonym), who became pregnant twice while taking the medication lumacaftor/ivacaftor (LUMA/IVA), was analyzed using thematic analysis. She described her experiences related to "Fertility and Pregnancy Surrounding LUMA/IVA," the major theme that emerged from her narrative. While there are anecdotal reports of infants conceived by women on LUMA/IVA and other CF precision medications, pregnancy rates and outcomes are not systematically tracked. Education about risks and benefits of these medications should be provided as part of comprehensive clinical care.

References

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Feb 14, 2017·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Sonya L HeltsheJennifer L Taylor-Cousar
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Citations

Aug 23, 2020·Journal of Clinical Medicine·Jennifer L Taylor-Cousar
Feb 4, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Kathleen J RamosJennifer L Taylor-Cousar
Mar 26, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Jennifer L Taylor-Cousar, Raksha Jain
Jun 3, 2021·Journal of Personalized Medicine·Raksha Jain, Jennifer L Taylor-Cousar
Dec 24, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Kate E O'ConnorGeorge M Solomon
Aug 19, 2021·Pediatric Pulmonology·Danielle M Goetz, Adrienne P Savant

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