PMID: 6412508Jul 1, 1983Paper

Two versus seven days penicillin treatment for acute otitis media. A placebo controlled trial in children

Acta Oto-laryngologica
K I Meistrup-LarsenJ Sederberg-Olsen

Abstract

103 children between 1 and 10 years of age participated in a double-blind placebo-controlled trial testing the effect of penicillin-V, 55 mg/kg/day, for two days versus seven days in acute otitis media. No significant differences could be demonstrated with regard to earache, healing of the tympanic membrane, tympanometry, fever or common cold symptoms. 76% in the group treated for seven days had a satisfactory course of the disease, compared to 71% in the group treated for two days (p greater than 0.1). In spite of the relatively small number of patients, it is concluded that the effect of penicillin for additional five days in acute otitis media after the initial treatment for two days, can at most be marginal. The advantages of a shortened treatment period are several; the authors have outlined a new treatment modality, consisting of masterful inactivity for 8-12 hours, penicillin-V for two days, and myringotomy in refractory cases, after a new evaluation by the otologist. We believe hereby to be able to reduce penicillin consumption in children with acute otitis media to about 15% of the previous level, without increasing the risk of serious complications.

References

Sep 1, 1979·International Journal of Pediatric Otorhinolaryngology·J ThomsenS Vesterhauge
Feb 1, 1981·Clinical Otolaryngology and Allied Sciences·N MygindH Sørensen
Feb 1, 1980·Drugs·R H Schwartz, D M Schwartz

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Citations

Apr 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D A KafetzisL Mitropoulos
Mar 1, 1986·The Journal of Laryngology and Otology·R Mills, J Gilsdorf
Jul 1, 1997·The Pediatric Infectious Disease Journal·M E Pichichero, R Cohen
Sep 23, 2000·The Pediatric Infectious Disease Journal·M E Pichichero
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Dec 1, 1986·European Journal of Pediatrics·N PrincipiE Massironi
Oct 11, 2002·Scandinavian Journal of Infectious Diseases·Lars SmåbrekkeSigne H Ringertz
Jan 1, 1990·Acta Oto-laryngologica·A HermanssonS Hellström
Jan 17, 2012·Annals of Emergency Medicine·Steven M Green, Donald M Yealy
Apr 2, 1998·Pediatric Annals·D A Conrad
Apr 11, 2008·International Journal of Pediatric Otorhinolaryngology·Michael E Pichichero, Janet R Casey
Sep 1, 1991·The Journal of Pediatrics·G S GiebinkJ Kempthorne
Jan 1, 1988·Acta Oto-laryngologica. Supplementum·H HarderE Strand
Jun 1, 1992·Clinical Otolaryngology and Allied Sciences·J Q ClaessenG J Hordijk
Nov 1, 1994·Clinical Pediatrics·J M ChamberlainB L Klein
Sep 9, 2010·The Cochrane Database of Systematic Reviews·Anita KozyrskyjKrystal Harvey
Mar 1, 1987·The Annals of Otology, Rhinology & Laryngology. Supplement·P KarmaK Launiala
Oct 1, 1991·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·A HermanssonK Prellner

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