Two-vial, LC-MS identification of ephedrine receptors from a solution-phase dynamic combinatorial library of over 9000 components

Journal of the American Chemical Society
R Frederick Ludlow, Sijbren Otto

Abstract

Reports on dynamic combinatorial chemistry have almost exclusively involved small libraries of 10-100 compounds. We now show how more than 9000 compounds can be screened in a single LC-MS analysis to reveal a series of new receptors that bind ephedrine in water. These results demonstrate the feasibility of screening DCLs that are substantially larger than the solution-phase libraries reported thus far.

Citations

Dec 31, 2011·Accounts of Chemical Research·Fabien B L Cougnon, Jeremy K M Sanders
Jan 24, 2012·Accounts of Chemical Research·Sijbren Otto
Apr 16, 2010·Journal of the American Chemical Society·R Frederick Ludlow, Sijbren Otto
Oct 29, 2010·Journal of the American Chemical Society·Max von DeliusDan-Tam D Tang
Nov 3, 2012·Journal of the American Chemical Society·Fabien B L CougnonJeremy K M Sanders
Feb 13, 2013·Journal of the American Chemical Society·Supratim Banerjee, Burkhard König
Jun 5, 2013·Journal of the American Chemical Society·Jianwei LiSijbren Otto
Oct 8, 2009·Journal of the American Chemical Society·Pornrapee Vongvilai, Olof Ramström
Oct 17, 2012·Organic Letters·Saleh HamiehSijbren Otto
Jan 14, 2012·Chemical Communications : Chem Comm·Anna V GromovaBenjamin L Miller
Mar 29, 2014·Chemical Communications : Chem Comm·Sébastien Ulrich, Pascal Dumy
May 12, 2012·Journal of Pharmaceutical and Biomedical Analysis·Toshimasa Toyo'oka
Oct 1, 2015·Organic & Biomolecular Chemistry·Filip UlatowskiJanusz Jurczak
Jan 29, 2014·Chemistry : a European Journal·Mihaela MatacheNiculina D Hădade
Feb 4, 2010·Chemical Communications : Chem Comm·Hideyuki OtsukaAtsushi Takahara
Nov 5, 2019·European Journal of Organic Chemistry·Alwin M HartmanAnna K H Hirsch
Jul 8, 2011·Chemistry : a European Journal·Zhihua LinRalf Warmuth
Dec 1, 2010·Chemical Communications : Chem Comm·Rosemary A R Hunt, Sijbren Otto
Jan 4, 2012·Angewandte Chemie·Fabien B L CougnonJeremy K M Sanders
Oct 27, 2011·Organic & Biomolecular Chemistry·Jörg M KleinJeremy K M Sanders
Dec 1, 2015·Chemical Science·Gang LiXiaoyu Li
Oct 30, 2009·Journal of Combinatorial Chemistry·Magnus PalmbladAndré M Deelder
Jun 8, 2021·Chemical Science·Mélissa DumartinJulien Leclaire
Feb 17, 2011·Journal of the American Chemical Society·Fabien B L CougnonJeremy K M Sanders
Feb 10, 2011·The Journal of Organic Chemistry·Ho Yu Au-YeungJeremy K M Sanders
Nov 10, 2018·Journal of the American Chemical Society·Yu ZhouXiaoyu Li

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