Two weeks of daily injections and continuous infusion of recombinant human growth hormone (GH) in GH-deficient adults. II. Effects on serum lipoproteins and lipoprotein and hepatic lipase activity

Metabolism: Clinical and Experimental
J OscarssonB A Bengtsson

Abstract

Recombinant human growth hormone (GH) administered as daily subcutaneous (SC) injections has been shown to affect serum lipoproteins in GH-deficient subjects. However, the effects of continuous infusion of GH on serum lipoproteins have not been investigated in GH-deficient adults. The aim of the present study was to compare effects of daily injections and continuous infusion of GH on lipoprotein metabolism. Recombinant human GH (0.25 U/kg/wk) was administered to nine GH-deficient adult men during a period of 14 days in two different ways, ie, as a daily SC injection at 8:00 PM and as a continuous SC infusion, with 1 month of washout between the treatments. Blood samples and tests were performed in the morning after an overnight fast before the start of GH treatment (day 0) and on day 2 and day 14 of treatment. Abdominal SC adipose tissue lipoprotein lipase (LPL), postheparin plasma LPL, and hepatic lipase (HL) activity were measured 120 minutes after the intake of 100 g glucose. Adipose tissue LPL activity decreased and postheparin plasma HL activity increased after 14 days of GH treatment irrespective of the mode of GH administration, whereas GH treatment had no effect on postheparin plasma LPL activity. Serum triglyceride and...Continue Reading

References

Jul 1, 1975·Scandinavian Journal of Clinical and Laboratory Investigation·P Nilsson-EhleP Belfrage
Mar 7, 1992·JAMA : the Journal of the American Medical Association·D J Rader, H B Brewer
May 1, 1992·European Journal of Clinical Investigation·C BaynesR S Elkeles
Apr 1, 1991·Diabetes Care·S M HaffnerD L Rainwater
Feb 11, 1991·Metabolism: Clinical and Experimental·R V FareseR H Eckel
May 15, 1990·The Biochemical Journal·G F Gibbons
Jun 1, 1990·The Journal of Clinical Endocrinology and Metabolism·L M WinerG Baumann
Jun 1, 1990·The Journal of Endocrinology·N Hoogerbrugge-vd LindenJ C Birkenhäger
Aug 1, 1989·The Journal of Clinical Endocrinology and Metabolism·C M AsplinW S Evans
Aug 1, 1989·British Journal of Obstetrics and Gynaecology·L ErikssonB Von Schoultz
Jan 1, 1989·International Journal of Epidemiology·U Keil, K Kuulasmaa
Apr 1, 1986·Metabolism: Clinical and Experimental·R ZechnerG M Kostner
Nov 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S JohanssonC Wilhelmsson
Sep 1, 1986·Metabolism: Clinical and Experimental·M W Stolar, G Baumann
Dec 4, 1985·Biochimica Et Biophysica Acta·J PetersonG Bengtsson-Olivecrona
Nov 1, 1984·Metabolism: Clinical and Experimental·C N SadurR H Eckel
Jan 1, 1984·Metabolism: Clinical and Experimental·R J Winter, O C Green
Feb 1, 1982·Metabolism: Clinical and Experimental·P R BlackettJ D Fesmire
Jul 1, 1980·Metabolism: Clinical and Experimental·T MuraseS Yoshida
Jan 1, 1981·The International Journal of Biochemistry·A Cryer
May 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·O WiklundL Wilhelmsen
Dec 1, 1994·Metabolism: Clinical and Experimental·G B SchaeferJ P Frindik
Feb 1, 1994·Metabolism: Clinical and Experimental·H de BoerJ A Schouten
Sep 1, 1993·Acta Endocrinologica·T RosénB A Bengtsson
Dec 1, 1993·Metabolism: Clinical and Experimental·R C CuneoP H Sönksen
Feb 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S EdénB A Bengtsson

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Citations

Jan 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Torben Laursen
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·E R ChristD L Russell-Jones
Nov 20, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jan-Ove JohanssonGudmundur Johannsson
Sep 27, 2012·American Journal of Physiology. Endocrinology and Metabolism·Andrea S CornfordJeffrey F Horowitz
Oct 23, 2008·Endocrine Reviews·Johannes D VeldhuisSteven M Pincus
Feb 26, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·M Zacharin
Jan 30, 2007·Journal of Endocrinological Investigation·C Höybye, M Rudling
Oct 6, 2009·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Archana VijayakumarDerek LeRoith
Sep 1, 1997·Metabolism: Clinical and Experimental·D BänschA von Eckardstein
Apr 1, 2016·Medicinal Research Reviews·Wing Yan So, Po Sing Leung
Aug 31, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·B P Hauffa
Jul 27, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·G Johannsson, J O Jørgensen
Mar 25, 2016·European Journal of Endocrinology·Jens Sandahl ChristiansenKevin Yuen
Jul 29, 2004·American Journal of Physiology. Endocrinology and Metabolism·Caroline AméenJan Oscarsson
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·B A BengtssonP H Sonken
Jul 12, 2014·The Journal of Clinical Endocrinology and Metabolism·Michael Højby RasmussenMette Suntum
May 9, 2003·American Journal of Physiology. Endocrinology and Metabolism·Michael D JensenAlan Cherrington
May 9, 2003·American Journal of Physiology. Endocrinology and Metabolism·Bob OlssonJan Törnell
Nov 10, 2001·American Journal of Physiology. Endocrinology and Metabolism·F FrickJ Oscarsson
Nov 13, 2003·Physiological Genomics·Petra Tollet-EgnellGunnar Norstedt

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