Two-year follow-up of changes in clinical chemistry in Singaporean Norplant-2 rod acceptors: metabolic changes

Contraception
K SinghS S Ratnam

Abstract

In this longitudinal study involving 100 Singaporean acceptors, the effects of Norplant-2 rods on metabolic function was evaluated. The mean serum bilirubin during the second year remained significantly raised from its preinsertion value (p less than 0.001). Furthermore the total proteins and globulin were still significantly decreased (p less than 0.001). Thus with respect to liver function, the results still indicate possible dysfunction at the end of two years. As regards lipid metabolism, the serum triglycerides, total cholesterol and LDL-cholesterol still remained significantly decreased at the end of two years when compared to preinsertion values. The HDL-cholesterol levels which showed no significant change during the first year of use decreased significantly during the second year of use. As a result the HDL-cholesterol/Total cholesterol - HDL-cholesterol decreased significantly and was 12.0% lower than the pre-insertion ratio (p less than 0.01). Similarly the LDL-cholesterol/HDL-cholesterol increased during the second year of use and was 2.6% higher than its preinsertion ratio. However, this increase was still not statistically significant. As we have not incorporated a simultaneous non-steroid treated control group, t...Continue Reading

Citations

Jun 1, 1990·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·K SinghS S Ratnam
Mar 1, 1990·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·K SinghS S Ratnam
Mar 1, 1991·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·Y BalaS Majumdar
Dec 1, 1989·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·K SinghS S Ratnam
Feb 28, 2002·Contraception·Laneta J Dorflinger
Jul 1, 1992·Contraception·J C KonjeO A Ladipo
Nov 25, 2000·Obstetrics and Gynecology Clinics of North America·K R Meckstroth, P D Darney
Aug 1, 1991·Contraception·J C KonjeO A Ladipo

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