PMID: 3771979Nov 1, 1986Paper

Two-year follow-up of elderly patients with mixed depression and dementia. Clinical and electroencephalographic sleep findings

Journal of the American Geriatrics Society
C F ReynoldsD E Sewitch

Abstract

In a two-year follow-up of 16 patients with mixed symptoms of depression and dementia, eight showed clinical improvement and eight showed deterioration. Improvement at two-year follow-up was associated with several baseline measures: a Folstein Mini-Mental State score of 21 or greater, a Hamilton Depression score of 21 or greater, and a sleep efficiency of less than 75%. These findings suggest that in the elderly with mixed symptoms of depression and dementia, a more favorable outcome is associated with initially greater depressive symptomatology, higher cognitive function, and moderate sleep continuity disturbance ("early morning awakening").

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Citations

Nov 16, 2013·The Psychiatric Clinics of North America·Sarah Shizuko Morimoto, George S Alexopoulos
Jan 28, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Christopher C ColendaGloria E Sarto
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Feb 7, 2015·Annals of the New York Academy of Sciences·Sarah Shizuko MorimotoGeorge S Alexopoulos
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Aug 18, 2004·Sleep Medicine Reviews·M Kerkhofs
Mar 31, 2015·Psychiatric Annals·Sarah Shizuko MorimotoGeorge S Alexopoulos
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Dec 17, 2003·International Journal of Geriatric Psychiatry·Meryl A ButtersSteven T DeKosky
Jun 27, 2008·Alzheimer Disease and Associated Disorders·Meryl A ButtersCarolyn C Meltzer
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Nov 15, 1996·Biological Psychiatry·G S ZubenkoB B Kaplan

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