Two-year follow-up of Helicobacter pylori infection in C57BL/6 and Balb/cA mice

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Xin WangT Wadström

Abstract

Helicobacter pylori infection is associated with chronic gastritis, peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. We previously found high-grade lymphoma after 13 months' H. pylori infection in C57BL/6 mice. In this study we followed H. pylori infection by three different isolates in C57BL/6 and Balb/cA mice for 23 months. Six-week-old C57BL/6 and Balb/cA mice were infected with H. pylori strains 119p (CagA+, VacA+), SS1 (CagA+, VacA+) and G50 (CagA-, VacA-). Mice were followed at 2 weeks, 10 weeks and 23 months post-inoculation (p.i.) by culture, histopathology and serology. Strain G50 was only reisolated from mice 2 weeks p.i. There was no difference in colonization between strain 119p and SS1 at 10 weeks p.i., whereas SS1 gave 100% colonization versus 119p gave 50% 23 months p.i. Interestingly, the inflammation score was higher in mice infected with strain 119p than with SS1 10-week p.i., and there were lymphoepithelial lesions in mice infected with strain 119p and G50 but not with SS1 at 23 months post-infection. Eight mice infected with strains 119p and G50 developed gastric lymphoma (grade 5 and 4). One C57BL/6 mouse infected with strain 119p developed hepatocellular carcinoma after 23 months. Immunoblot...Continue Reading

References

Mar 3, 1995·International Journal of Cancer. Journal International Du Cancer·H MøllerH Vainio
May 1, 1994·Japanese Journal of Cancer Research : Gann·S TsuganeK Sugano
Jan 1, 1996·The American Journal of Surgical Pathology·P G Isaacson
Feb 1, 1997·Journal of Clinical Microbiology·I NilssonT Wadström
Jan 9, 1998·The American Journal of Surgical Pathology·E D HsiB Schnitzer
Aug 1, 1997·Journal of Medical Microbiology·X WangT Wadström
Mar 26, 1998·European Journal of Gastroenterology & Hepatology·T VorobjovaR Uibo
Aug 28, 1998·Gastroenterology·T WatanabeM Nakao
Nov 11, 1998·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·X WangP Aleljung
Feb 6, 1999·Histopathology·C De Wolf-Peeters, R Achten
Mar 4, 1999·Histopathology·H BouzoureneE Saraga
Apr 25, 2000·Cancer Letters·B SchmausserH Stopper
Oct 6, 2000·Journal of the National Cancer Institute·W C YouG W Xu
Feb 13, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·X WangT Wadström
Apr 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A MorgnerE Bayerdörffer
Feb 5, 2002·Journal of Clinical Microbiology·Christo AtanassovJean-Louis Fauchère
Mar 20, 2002·Current Gastroenterology Reports·Asa Ljungh, Torkel Wadström

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Citations

Feb 11, 2005·Current Opinion in Gastroenterology·Luke C Bi, Jonathan D Kaunitz
Dec 25, 2010·Digestive Diseases and Sciences·Wongwarut BoonyanugomolBanchob Sripa
Feb 11, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Wongwarut BoonyanugomolAmporn Chamsuwan
Apr 15, 2004·Alimentary Pharmacology & Therapeutics·D M Pritchard, S M C Przemeck
May 27, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sheng LiuYan Zhang
Jul 26, 2014·Journal of Gastric Cancer·Sungsook YuKi Taek Nam
Apr 28, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Y HuangC Zhu
Jan 27, 2016·Journal of Gastroenterology and Hepatology·Ashleigh R PohTracy L Putoczki
Sep 10, 2009·Journal of Immunoassay & Immunochemistry·Abdelfattah M AttallahIbrahim El-Dosoky
Jun 11, 2005·World Journal of Gastroenterology : WJG·Yan ZhangZhao-Hui Chen
Sep 9, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Moon-Jung GooKyu-Shik Jeong
Aug 2, 2013·Experimental Animals·Yumiko KiriharaTsutomu Kurosawa
Nov 13, 2013·Cancers·Yoku HayakawaTimothy C Wang
Sep 8, 2015·Current Protocols in Pharmacology·Carrie A DuckworthD Mark Pritchard
Oct 1, 2004·World Journal of Gastroenterology : WJG·Zun XiangHuai-De Huang
Aug 27, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hadi Maleki KakelarYadollah Omidi

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