Two-year outcome after recurrent first trimester miscarriages: prognostic value of the past obstetric history

Archives of Gynecology and Obstetrics
Christiane KlingDieter Kabelitz

Abstract

Recurrent miscarriage (RM) is a stressful condition which gives rise to extensive diagnostic evaluation and is seen as a potentially curable maternal disease. Nevertheless, epidemiological data have shown that outcome is related to fertility. In addition to maternal age and number of preceding miscarriages, further markers derived from the past history may support counselling. Observational trial comprising 228 couples who were referred between 1996 and 2003 for immunological evaluation at maternal ages 20-39 years after three or more spontaneously conceived primary first trimester miscarriages. They were interviewed in 2005, ongoing pregnancies were followed up until birth in 2006. Past obstetric history was correlated with 2 year cumulative pregnancy and delivery rates (CPR, CDR). CPR and CDR were 206/228 (90.4 %) and 174/228 (76.4 %). Duration of infertility was associated with lower CPR (up to 3/>3 years, p < 0.01), whereas age and number of preceding losses inversely correlated with CDR (<35 years/35-39 years, p < 0.002; 3/>3 miscarriages, p < 0.002). Detection of an embryonic heart beat in 2-3 of the first three miscarriages resulted in favourable outcome (CPR: p < 0.02, CDR: p < 0.002). Prognosis was excellent in younger...Continue Reading

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Citations

Oct 21, 2016·Archives of Gynecology and Obstetrics·Ritva NissiAnne Talvensaari-Mattila
Oct 17, 2016·Archives of Gynecology and Obstetrics·Maria Elisabetta Coccia, Francesca Rizzello
Jul 15, 2017·Journal of Assisted Reproduction and Genetics·Ángela Porras-DorantesJosé Elías García-Ortiz
Oct 19, 2017·Archives of Gynecology and Obstetrics·Christiane KlingDieter Kabelitz
Dec 12, 2020·Nature Reviews. Disease Primers·Evdokia DimitriadisJan J Brosens
Oct 1, 2020·Saudi Journal of Biological Sciences·Shafat AliFahad A Al-Misned

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Methods Mentioned

BETA
pregnancy test

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