Two-Year Outcomes After Transcatheter Aortic Valve Replacement With Mechanical vs Self-expanding Valves: The REPRISE III Randomized Clinical Trial

JAMA Cardiology
Michael J ReardonReprise III Investigators

Abstract

To our knowledge, REPRISE III is the first large randomized comparison of 2 different transcatheter aortic valve replacement platforms: the mechanically expanded Lotus valve (Boston Scientific) and self-expanding CoreValve (Medtronic). To evaluate outcomes of Lotus vs CoreValve after 2 years. A total of 912 patients with high/extreme risk and severe, symptomatic aortic stenosis enrolled between September 22, 2014, and December 24, 2015, were randomized 2:1 to receive Lotus (607 [66.6%]) or CoreValve (305 [33.4%] at 55 centers in North America, Europe, and Australia. The first 2-year visit occurred on October 17, 2016, and the last was conducted on April 12, 2018. Clinical and echocardiographic assessments are complete through 2 years and will continue annually through 5 years. All-cause mortality and all-cause mortality or disabling stroke at 2 years. Other clinical factors included overall stroke, disabling stroke, repeated procedures, rehospitalization, valve thrombosis, and pacemaker implantation. Echocardiographic analyses included effective orifice area, mean gradient, and paravalvular leaks (PVLs). Of 912 participants, the mean (SD) age was 82.8 (7.3) years, 465 (51%) were women, and the mean (SD) Society of Thoracic Surg...Continue Reading

References

Jun 7, 2011·The New England Journal of Medicine·Craig R SmithUNKNOWN PARTNER Trial Investigators
Mar 27, 2012·The New England Journal of Medicine·Susheel K KodaliUNKNOWN PARTNER Trial Investigators
Apr 1, 2014·The New England Journal of Medicine·David H AdamsUNKNOWN U.S. CoreValve Clinical Investigators
Jun 10, 2015·Journal of the American College of Cardiology·Michael J ReardonJeffrey J Popma
Apr 7, 2016·Journal of the American College of Cardiology·G Michael DeebUNKNOWN CoreValve US Clinical Investigators
Jun 18, 2018·JACC. Cardiovascular Imaging·Rebecca T HahnJae K Oh
Sep 27, 2018·Journal of the American College of Cardiology·Thomas G GleasonUNKNOWN CoreValve U.S. Pivotal High Risk Trial Clinical Investigators
Nov 18, 2018·Journal of the American College of Cardiology·Samir R KapadiaUNKNOWN PARTNER Trial Investigators

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Citations

Aug 12, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Aung MyatDavid Hildick-Smith
Aug 15, 2020·Expert Review of Cardiovascular Therapy·Nikolaos PoulisMaximilian Y Emmert
Mar 1, 2020·Cardiology and Therapy·Morgan H Randall, Anthony A Bavry
Jul 30, 2020·Current Cardiology Reports·Ryan MarkhamR Sharma
Sep 16, 2020·European Heart Journal·Arnold C T NgJeroen J Bax
Jan 9, 2021·European Heart Journal. Quality of Care & Clinical Outcomes·Andrew M Goldsweig, Harsh Golwala
Jun 12, 2020·Current Problems in Cardiology·Tianyu JiangJigar Patel
Feb 20, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Raúl MorenoHolger Thiele
May 8, 2021·Journal of the American College of Cardiology·Colin M Barker
May 12, 2021·International Journal of Cardiology·Fabrizio D'AscenzoGaetano Maria De Ferrari
Aug 12, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Justine M RavauxRoberto Lorusso

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