Two-Year Outcomes of a Population-Based Intervention for Preschool Language Delay: An RCT

Pediatrics
Melissa WakeSheena Reilly

Abstract

We have previously shown short-term benefits to phonology, letter knowledge, and possibly expressive language from systematically ascertaining language delay at age 4 years followed by the Language for Learning intervention. Here, we report the trial's definitive 6-year outcomes. Randomized trial nested in a population-based ascertainment. Children with language scores >1.25 SD below the mean at age 4 were randomized, with intervention children receiving 18 1-hour home-based therapy sessions. Primary outcome was receptive/expressive language. Secondary outcomes were phonological, receptive vocabulary, literacy, and narrative skills; parent-reported pragmatic language, behavior, and health-related quality of life; costs of intervention; and health service use. For intention-to-treat analyses, trial arms were compared using linear regression models. Of 1464 children assessed at age 4, 266 were eligible and 200 randomized; 90% and 82% of intervention and control children were retained respectively. By age 6, mean language scores had normalized, but there was little evidence of a treatment effect for receptive (adjusted mean difference 2.3; 95% confidence interval [CI] -1.2 to 5.7; P = .20) or expressive (0.8; 95% CI -1.6 to 3.2; P...Continue Reading

References

Aug 1, 1991·Journal of Speech and Hearing Research·R PaulP S Dahm
Jul 1, 1997·Journal of Child Psychology and Psychiatry, and Allied Disciplines·R Goodman
Sep 4, 2003·Developmental Psychology·Julia M CarrollJim Stevenson
Nov 18, 2003·Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association·James W VarniDouglas Skarr
Feb 1, 2005·Journal of Child Psychology and Psychiatry, and Allied Disciplines·J CleggM Rutter
Jan 20, 2007·BMJ : British Medical Journal·Rafael PereraPatricia Yudkin
Dec 18, 2007·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Claudine Bowyer-CraneCharles Hulme
Dec 29, 2007·Language, Speech, and Hearing Services in Schools·Frank M Cirrin, Ronald B Gillam
May 29, 2008·Journal of Speech, Language, and Hearing Research : JSLHR·James LawXuyang Zhang
Dec 3, 2009·Journal of Speech, Language, and Hearing Research : JSLHR·James LawSamantha Parsons
Oct 19, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Gemma K StrongCharles Hulme
Sep 19, 2012·Archives of Pediatrics & Adolescent Medicine·Sharon GoldfeldMelissa Wake
Nov 28, 2012·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Silke FrickeMargaret J Snowling
Aug 22, 2014·International Journal of Language & Communication Disorders·Sheena ReillyMelissa Wake

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Citations

Jun 15, 2016·International Journal of Language & Communication Disorders·Allyson HaleySilke Fricke
Feb 14, 2018·Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP)·Maria LennoxDavid Trembath
Sep 27, 2019·International Journal of Language & Communication Disorders·Ha N D LeLisa Gold
Jan 27, 2019·International Journal of Language & Communication Disorders·Astrid Kruythoff-BroekmanNoëlle Uilenburg
Mar 3, 2020·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Ha N D LeSheena Reilly
Apr 4, 2021·Brain Sciences·Sara RinaldiPierluigi Zoccolotti
Feb 10, 2017·Pediatrics·Cristina McKeanFiona Mensah
Mar 29, 2018·Pediatrics·Qian-Wen XieCecilia L W Chan

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