PMID: 2497039Feb 1, 1989Paper

Two-year toxicity and carcinogenicity studies of ampicillin trihydrate and penicillin VK in rodents

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
J K DunnickJ K Haseman

Abstract

Toxicology and carcinogenesis studies of ampicillin trihydrate and penicillin VK, two widely used beta-lactam antibiotics, were performed in F344/N rats and B6C3F1 mice. In these studies ampicillin trihydrate was administered for 2 years to rats at doses of 0, 750, or 1500 mg/kg and to mice at doses of 0, 1500, or 3000 mg/kg, and penicillin VK was administered to rats and mice at doses of 0, 500, or 1000 mg/kg. Both drugs were administered by oral gavage in corn oil. Toxic lesions of the stomach were seen in rats and mice after ampicillin trihydrate administration and in mice after penicillin VK administration. In male rats that received ampicillin trihydrate there was a marginal increase in incidence of mononuclear cell leukemia and pheochromocytomas of the adrenal gland medulla. There was no evidence for carcinogenic activity in female rats or male and female mice after ampicillin trihydrate administration or in rats and mice after penicillin VK administration.

Citations

Oct 28, 2006·Toxicologic Pathology·Andrew W Suttie
May 25, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Johnson ThomasPamela J Spencer
Jul 24, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·R DündarözV Baltaci
Jul 14, 2018·Probiotics and Antimicrobial Proteins·Ismail M FareezKalavathy Ramasamy
Sep 19, 2019·Toxicologic Pathology·Cynthia L Willard-MackCharlotte M Keenan
Oct 9, 2021·Communications Biology·Yamal Al-RamahiVíctor de Lorenzo

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