Two years later - Revisiting autobiographical memory representations in vmPFC and hippocampus

Neuropsychologia
Heidi M Bonnici, Eleanor A Maguire

Abstract

A long-standing question in memory neuroscience concerns how and where autobiographical memories of personal experiences are represented in the brain. In a previous high resolution multivoxel pattern analysis fMRI study, we examined two week old (recent) and ten year old (remote) autobiographical memories (Bonnici et al., 2012, J. Neurosci. 32:16982-16991). We found that remote memories were particularly well represented in ventromedial prefrontal cortex (vmPFC) compared to recent memories. Moreover, while both types of memory were represented within anterior and posterior hippocampus, remote memories were more easily distinguished in the posterior portion. These findings suggested that a change of some kind had occurred between two weeks and ten years in terms of where autobiographical memories were represented in the brain. In order to examine this further, here participants from the original study returned two years later and recalled the memories again. We found that there was no difference in the detectability of memory representations within vmPFC for the now 2 year old and 12 year old memories, and this was also the case for the posterior hippocampus. Direct comparison of the two week old memories (original study) with t...Continue Reading

Citations

Feb 21, 2019·Social Cognitive and Affective Neuroscience·Areeba AdnanGary R Turner
May 3, 2019·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Mohamad El HajJean-Louis Nandrino
Sep 29, 2019·Journal of Cognitive Neuroscience·Christelle LarzabalSimon J Thorpe
Sep 3, 2019·Journal of the International Neuropsychological Society : JINS·Michael D Kopelman
Jun 24, 2020·Cerebral Cortex·Cornelia McCormickEleanor A Maguire
Oct 5, 2019·Hippocampus·Robert J SutherlandHugo Lehmann
Jun 18, 2020·Cerebral Cortex·Chih-Chin Heather HsuChing-Po Lin
Jul 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Valerio SantangeloPatrizia Campolongo
May 1, 2020·Nature Communications·Ryan W CarlsonMolly J Crockett
Oct 3, 2020·Frontiers in Human Neuroscience·Alan R Harvey
Jul 28, 2020·Neuroscience and Biobehavioral Reviews·Iva K BrunecMorgan D Barense
Mar 3, 2021·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Yoshihide SeharaMikio Sawada
Mar 17, 2021·Proceedings of the National Academy of Sciences of the United States of America·Adrian W GilmoreAlex Martin

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