Two years of maintenance hemodialysis has a pronounced effect on arterial stiffness progression

Aging Clinical and Experimental Research
Agne Laucyte-CibulskieneMarius Miglinas

Abstract

The change of aortic stiffness, but not the particular baseline value, plays a crucial role in estimating the patient risk with end-stage renal disease. Therefore, we aimed to analyze the evolution of central and peripheral arterial stiffness in hemodialysis population without previous cardiovascular events during a 2-year follow-up. 60 hemodialysis patients (mean age 57.61 ± 13.01 years) were prospectively interviewed, and they underwent blood tests, chest X-ray for aortic calcification evaluation and pulse wave velocity (PWV) measurements at the baseline, after 6 months and after 2 years of observation period. We found significant progression of aortic PWV (12.73 vs. 14.24 m/s, p = 0.032) and regression of brachial PWV (11.53 vs. 8.85 m/s, p < 0.001). CRP increase influenced evolution of aortic PWV (β = 0.331, p = 0.031, R2 = 0.599). Higher β2-microglobulin values was related to the progression of aortic PWV (β = 0.219, p = 0.022, R2 = 0.568). Mean arterial blood pressure had influence only on the short-term arterial stiffness evolution. Patients on maintenance hemodialysis experience pronounced changes of arterial stiffness during the 2-year follow-up period. The progression of aortic stiffness is related to inflammatory res...Continue Reading

References

Jan 4, 1996·The New England Journal of Medicine·M J KlagJ Stamler
May 11, 1999·Circulation·J BlacherG M London
Mar 28, 2008·Kidney International·C MenaaS M Sprague
Jun 3, 2009·Hemodialysis International·Tetsuya OgawaKosaku Nitta
Jan 16, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tomoji MatsumaeTakao Saito
Feb 3, 2011·World Journal of Cardiology·Peter A McCullough, Aftab Ahmad
Apr 20, 2011·Kidney & Blood Pressure Research·Biagio Di IorioUNKNOWN INDEPENDENT study investigators
Nov 10, 2012·Journal of the American Society of Nephrology : JASN·Rukshana ShroffCatherine Shanahan
Mar 5, 2013·Calcified Tissue International·Meiting WuCecilia M Giachelli
May 9, 2013·Contributions to Nephrology·Merrill F EliasAdam Davey
Jun 1, 2011·Kidney International Supplements·Gerard LondonUNKNOWN for EUropean REnal and CArdiovascular Medicine working group of the European Renal Association–European Dialysis and Transpl
Feb 11, 2015·Journal of Molecular and Cellular Cardiology·Mingyi Wang, Ajay M Shah
May 20, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lesley A InkerAndrew S Levey
May 30, 2015·Contributions to Nephrology·Kosaku Nitta, Tetsuya Ogawa
Mar 7, 2017·Seminars in Dialysis·Laura Labriola, Michel Jadoul
Jul 1, 2017·Aging Clinical and Experimental Research·Agne Laucyte-CibulskieneKestutis Strupas

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Citations

Nov 16, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Justin LeeJawed Fareed

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