TXU (anti-CD7)-pokeweed antiviral protein as a potent inhibitor of human immunodeficiency virus.

Antimicrobial Agents and Chemotherapy
F M UckunD E Myers

Abstract

We have evaluated the clinical potential of TXU (anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate (TXU-PAP) as a new biotherapeutic anti-human immunodeficiency virus (anti-HIV) agent by evaluating its anti-HIV type 1 (anti-HIV-1) activity in vitro, as well as in a surrogate human peripheral blood lymphocyte-severe combined immunodeficient (Hu-PBL-SCID) mouse model of human AIDS. The present report documents in a side-by-side comparison the superior in vitro anti-HIV-1 activity of TXU-PAP compared to the activities of zidovudine, 2',3'-didehydro-2',3'-dideoxythymidine, unconjugated PAP, and B53-PAP, an anti-CD4-PAP immunoconjugate. Notably, TXU-PAP elicited potent anti-HIV activity in the Hu-PBL-SCID mouse model of human AIDS without any side effects and at doses that were very well tolerated by cynomolgus monkeys. Furthermore, plasma samples from TXU-PAP-treated cynomolgus monkeys showed potent anti-HIV-1 activity in vitro.

References

Mar 4, 1977·Annals of the New York Academy of Sciences·M A UsseryB Hardesty
Jan 1, 1992·Pharmacology & Therapeutics·J D Irvin, F M Uckun
Apr 15, 1991·Annals of Internal Medicine·A S FauciG Pantaleo
Feb 15, 1991·Science·D E MosierS A Spector
Jul 30, 1987·The New England Journal of Medicine·D D HoJ C Kaplan
Jun 1, 1980·Antimicrobial Agents and Chemotherapy·G M Aron, J D Irvin
Mar 1, 1983·Antimicrobial Agents and Chemotherapy·G J TeltowG M Aron
Jan 1, 1983·Pharmacology & Therapeutics·J D Irvin

❮ Previous
Next ❯

Citations

Mar 29, 2011·Advances in Dental Research·Y Chu, H Liu
Jan 5, 2002·Antiviral Chemistry & Chemotherapy·T K VenkatachalamF M Uckun
Mar 14, 2002·Journal of Ethnopharmacology·Kavita Vermani, Sanjay Garg
Nov 27, 2002·Antiviral Chemistry & Chemotherapy·Fatih M UckunT K Venkatachalam
Mar 13, 2003·Antiviral Chemistry & Chemotherapy·T K VenkatachalamF M Uckun
Nov 21, 2019·Current Protein & Peptide Science·Snober Shabeer WaniTanveer A Dar
Jul 15, 1999·Biochemical and Biophysical Research Communications·F RajamohanF M Uckun
Jul 27, 1999·Protein Expression and Purification·F RajamohanF M Uckun
Sep 15, 2005·Phytotherapy Research : PTR·Kaleab AsresSimon Gibbons
Jun 18, 2004·Toxicologic Pathology·Osmond J D'CruzFatih M Uckun
Jun 22, 2000·Biology of Reproduction·O J D'CruzF M Uckun
Jan 6, 2001·Antiviral Chemistry & Chemotherapy·T K VenkatachalamF M Uckun
Feb 13, 2001·Fertility and Sterility·O J D'Cruz, F M Uckun
Aug 13, 2003·Journal of Applied Microbiology·S A A Jassim, M A Naji
Jun 10, 2004·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·O J D'CruzF M Uckun
Aug 13, 2004·Biology of Reproduction·Osmond J D'CruzFatih M Uckun
Dec 24, 2008·AIDS Research and Therapy·M FrittsS A Andrade

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.