Tying the knot: occurrence and possible significance of gene fusions in plant metabolism and beyond

Journal of Experimental Botany
Jillian M Hagel, Peter J Facchini

Abstract

Gene fusions have recently attracted attention especially in the field of plant specialized metabolism. The occurrence of a gene fusion, in which originally separate gene products are combined into a single polypeptide, often corresponds to the functional association of individual components within a single metabolic pathway. Examples include gene fusions implicated in benzylisoquinoline alkaloid (BIA), terpenoid, and amino acid biosynthetic pathways, in which distinct domains within a fusion catalyze consecutive, yet independent reactions. Both genomic and transcriptional mechanisms result in the fusion of gene products, which can include partial or complete domain repeats and extensive domain shuffling as evident in the BIA biosynthetic enzyme norcoclaurine synthase. Artificial gene fusions are commonly deployed in attempts to engineer new or improved pathways in plants or microorganisms, based on the premise that fusions are advantageous. However, a survey of functionally characterized fusions in microbial systems shows that the functional impact of fused gene products is not straightforward. For example, whereas enzyme fusions might facilitate the metabolic channeling of unstable intermediates, this channeling can also occu...Continue Reading

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Citations

Sep 20, 2017·Journal of Experimental Botany·Tessa Moses, Alain Goossens
Sep 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eisuke KatoJun Kawabata
Mar 1, 2018·Natural Product Reports·J M Hagel, P J Facchini
Feb 15, 2018·BMC Genomics·Jackson A KillianRalf Bundschuh
Jun 29, 2018·Biotechnology for Biofuels·Chunman ZuoYing Xu
Aug 20, 2020·Nature Chemical Biology·Martin St Maurice
Feb 20, 2019·International Journal of Molecular Sciences·Tatiana Y GorpenchenkoVictor P Bulgakov
Jun 9, 2021·Nature Chemical Biology·Tristan de RondBradley S Moore

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