PMID: 9527107Apr 4, 1998Paper

Tympanic membrane perforations in the diabetic rat: a model of impaired wound healing

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
J T Vrabec

Abstract

Animal models of type I and type II diabetes mellitus have been studied intensively in an effort to define the pathophysiology of the diabetic condition. An often-observed clinical manifestation of diabetes is poor wound repair. Thus diabetic animals have emerged as useful models for the study of impaired wound healing. The healing of acute tympanic membrane (TM) perforations in diabetic animals has not been reported. This investigation compares time to closure of a standardized TM perforation in rats with streptozotocin-induced diabetes, Zucker diabetic fatty rats, and normal control rats. The Zucker diabetic fatty rats demonstrate a significantly prolonged time to closure compared with the other two groups. This animal model may be useful for future study of TM wound repair.

References

Mar 1, 1977·The Journal of Surgical Research·W H Goodson, T K Hung
Oct 1, 1992·Diabetes/metabolism Reviews·E Shafrir
Oct 1, 1991·Clinics in Dermatology·L E Millikan
Jan 1, 1988·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M LaatoB Gerdin
Nov 1, 1983·The Journal of Surgical Research·R H Bell, R J Hye
Sep 7, 2007·ANZ Journal of Surgery·Nelson C Goldman

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Citations

Feb 25, 2011·Obesity Surgery·Liyu XingMichael George Franz
Aug 26, 1998·The Laryngoscope·J T VrabecJ T Mader
Oct 1, 2014·Journal of Diabetes·Mihir GuptaKalpna Gupta
Feb 10, 2011·The Laryngoscope·Holger KaftanIngrid Klöting
Mar 22, 2012·Anatomia, histologia, embryologia·S SommerauerG F Schusser

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