Tyndallometry for follow-up of iodine-125 brachytherapy of uveal malignant melanomas. Report of 2 patients

Klinische Monatsblätter für Augenheilkunde
N X NguyenW Strunk

Abstract

Previous studies that used the noninvasive laser flare-cell meter (LFCM) have demonstrated impairment of the blood-aqueous barriers in eyes with uveal melanoma. Herein we report the use of the LFCM in the follow-up of brachytherapy in 2 patients after radiation therapy with iodine 125 for choroidal melanoma. Two women (59-and 57-years-old) with choroidal melanoma who were treated with iodine 125-plaque, were followed-up for 24 and 36 months, respectively. Complete ophthalmological examination including tyndallometry and echography were performed regularly. Following radiation, patient 1 showed decreasing flare values, that returned to normal level one year after radiation (5.9 photon counts/ms). The decrease in flare values correlated with fundoscopic and ultrasonographic signs of tumor regression. After 14 months, flare values suddenly increased up to 15 photon counts/ms, and fluorescein angiography revealed signs of radiation retinopathy. In patient 2, flare values (18.0 photon counts/ms) did not decrease after radiation but showed further increase one year after radiation (39.0 photon counts/ms). Slitlamp biomicroscopy revealed segmental iris neovascularization from 6 to 9 hours, corresponding to the site of the previous pla...Continue Reading

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