PMID: 9534750Apr 16, 1998Paper

Type 1 cytokine response and treatment outcome of genital HPV lesions

Genitourinary Medicine
G StellatoJ Paavonen

Abstract

To determine the role of type 1 cytokines as predictors of response to treatment of genital HPV lesions with laser ablation with or without adjuvant systemic interferon alpha 2b (IFN-alpha). Measurement of serum interleukin 2 (IL-2), IL-2 soluble receptor alpha (sIL-2 alpha), interferon gamma, and human papilloma virus (HPV) DNA in patients undergoing treatment of genital HPV lesions with carbon dioxide laser and systemic IFN-alpha. A randomised, placebo controlled study of 92 cases with 6 months of follow up. High IL-2/sIL-2 alpha was associated with 60% to 70% protection against recurrences both in the IFN-alpha and placebo groups (OR = 0.4, 90%, CI 0.1-2.5; OR = 0.3, 90% CI 0.0-1.8, respectively). Diagnostic phase serum IL-2 predicted favourable outcome (OR = 0.2, 90% CI 0.0-1.0) in women with high load of HPV DNA or HPV 16/18 DNA regardless of the adjuvant therapy. Serum IL-2 determinations may identify women with good prognosis following laser ablation of genital HPV lesions.

References

Jan 1, 1992·Advances in Cancer Research·E Kedar, E Klein
May 1, 1991·American Journal of Obstetrics and Gynecology·P NieminenJ Paavonen
Jul 1, 1994·Antiviral Research·R Cirelli, S K Tyring
Jun 1, 1994·Journal of the National Cancer Institute·S M LippmanH Goepfert
Mar 1, 1994·Sexually Transmitted Diseases·P NieminenJ Paavonen

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Citations

Nov 26, 2003·Journal of Biotechnology·Weidong DuE Marion Schneider
Mar 23, 2005·Virology·Ana Paula M FernandesEduardo A Donadi
Mar 9, 2006·American Journal of Obstetrics and Gynecology·Daron G FerrisUNKNOWN ALTS Group

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