Type 1 diabetes alters brain cannabinoid receptor expression and phosphorylation status in rats

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
C Díaz-AsensioO Casis

Abstract

One of the most common symptoms of diabetes is extreme hunger, but the brain mechanism underlying this hyperphagia is unknown. The endocannabinoid system has emerged as one of the main food intake regulators in the brain. However, the effects of type 1 diabetes on the endocannabinoid system are not completely known. Thus, the aim of the present work is to establish the possible alterations induced by type 1 diabetes on the brain endocannabinoid system in rats. Western blot and immunocytochemistry were used to measure CB1 and phosphorylated CB1 receptor expression in several prosencephalic regions in streptozotocin-induced type 1 diabetic rats. Serum leptin levels were measured by ELISA. CB1 receptor expression was increased in striatum and hypothalamus of diabetic animals, with no changes in other brain areas studied. CB1 receptor phosphorylation was also increased in the same brain areas. Type 1 diabetes induced significant weight loss, and serum leptin levels were severely decreased. These results reinforce the possible role of the CB1 receptor as a pharmacological target for the clinical management of appetite in diabetic patients.

Citations

Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura OrioGeorge F Koob
Aug 29, 2012·British Journal of Pharmacology·R B LaprairieE M Denovan-Wright
Oct 19, 2007·PLoS Biology·Jason M WilliamsAurelio Galli
Aug 25, 2017·International Journal of Molecular Sciences·Ivonne Bazwinsky-WutschkeFaramarz Dehghani
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Enrique Sánchez-PastorMiguel Huerta

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