Type 1 diabetes compromises plasma arachidonic and docosahexaenoic acids in newborn babies

Lipids
K GhebremeskelM Crawford

Abstract

The activity of delta6- and delta5-desaturase, enzymes required for the synthesis of AA and DHA, are impaired in human and experimental diabetes. We have investigated whether neonates of type 1 diabetic women have compromised plasma AA and DHA at birth. Cord blood was obtained from healthy babies born to mothers with (n = 31) and without (n = 59) type 1 diabetes. FA composition of plasma choline phosphoglycerides (CPG), TG, and cholesterol esters (CE) was assayed. The neonates of the diabetics had lower levels of AA (20:4n-6, P< 0.0001), adrenic acid (22:4n-6, P < 0.01), sigman-6 metabolites (P < 0.0001), docosapentaenoic acid (22:5n-3, P < 0.0001), DHA (22:6n-3, P < 0.0001), sigman-3 (P < 0.0001), and sigman-3 metabolites (P< 0.0001) in CPG compared with the corresponding babies of the nondiabetic mothers. Similarly, they had lower levels of AA (P< 0.05), sigman-6 metabolites (P < 0.05), DHA (P< 0.0001), and sigman-3 metabolites (P< 0.01) in plasma CE. There was also a nonsignificant reduction of AA and DHA in TG in the babies of the diabetic group. The current investigation indicates that healthy neonates born to mothers with type 1 diabetes have highly compromised levels of AA and DHA. These nutrients are of critical importa...Continue Reading

References

Apr 1, 1992·The Journal of Pediatrics·M Martinez
Apr 1, 1992·Journal of Pediatric Gastroenterology and Nutrition·A A LeafM A Crawford
May 1, 1991·Molecular and Cellular Endocrinology·R A IgalI N de Gómez Dumm
Sep 26, 1991·The New England Journal of Medicine·T RizzoK Burns
Apr 1, 1989·Metabolism: Clinical and Experimental·S el BoustaniA Crastes de Paulet
Jan 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D P MikhailidisP Dandona
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M NeuringerS Luck
Jan 1, 1985·Progress in Lipid Research·P S Sastry
Jan 1, 1985·Biology of the Neonate·J ChambazG Bereziat
Oct 1, 1985·The Journal of Clinical Endocrinology and Metabolism·R S Tilvis, T A Miettinen
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R T HolmanD M Brown
Jan 1, 1983·Progress in Lipid Research·S J Fliesler, R E Anderson
Jun 1, 1980·Early Human Development·M T ClandininG W Chance
Mar 1, 1995·Archives of Disease in Childhood·J FarquharsonF Cockburn
Jan 1, 1994·World Review of Nutrition and Dietetics·G VilbergssonL Svennerholm
Aug 1, 1994·The American Journal of Clinical Nutrition·M MakridesR A Gibson
Sep 1, 1994·The American Journal of Clinical Nutrition·M B JacksonA M Ferris
Apr 7, 1993·Biochimica Et Biophysica Acta·J P PoissonA Crastes de Paulet
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·N SalemR Uauy
Jan 1, 1996·Annals of Nutrition & Metabolism·H S WeisingerA J Sinclair
Oct 1, 1996·American Journal of Obstetrics and Gynecology·E A ReeceG Sloskey
Oct 1, 1996·Acta Paediatrica·Y YamashitaH Kato
Dec 9, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·V LakinD Grubb
Jan 5, 2000·The American Journal of Clinical Nutrition·A K Dutta-Roy
Feb 7, 2001·The American Journal of Clinical Nutrition·C WilliamsUNKNOWN Avon Longitudinal Study of Pregnancy and Childhood Study Team

❮ Previous
Next ❯

Citations

Sep 14, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Emilio Herrera, Henar Ortega-Senovilla
Oct 5, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Jinping ZhaoHope A Weiler
Oct 20, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Jinping ZhaoHope A Weiler
Sep 3, 2008·Reproductive Toxicology·Stephen J Genuis
Nov 26, 2010·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Vickie H Y WongAlgis J Vingrys
Mar 5, 2011·Maternal & Child Nutrition·Lotte Lauritzen, Susan E Carlson
Apr 27, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·B A ThomasMichael A Crawford
Mar 14, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Edina BerberovicJosip Djelmis
Oct 22, 2016·Current Diabetes Reports·Brian J SongLouis R Pasquale
Apr 21, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Pauline LéveilléMélanie Plourde
Nov 23, 2017·Pediatric Research·Eli J LouwagieMichelle L Baack
Mar 13, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Brikene ElshaniArmond Daci
May 4, 2018·The Journal of Clinical Endocrinology and Metabolism·Josip DjelmisSlavko Oreskovic
Jan 28, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Anita MorandiClaudio Maffeis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.