Type 1 diabetes environmental factors and correspondence analysis of HLA class II genes in the Yemenite Jewish community in Israel

Diabetes Care
N WeintrobP Vardi

Abstract

The Israeli Yemenite Jewish community has displayed an exceptionally rapid increase in the frequency of type 1 diabetes, having the highest rate of all Israeli ethnic groups. We studied the role of the environment, in relation to the nature and frequency of HLA class II genes, to evaluate its possible involvement in the development of diabetes. We interviewed 196 elderly Yemenite women, who had immigrated to Israel as adults, in programmed encounters about signs and symptoms of type 1 diabetes, infant feeding customs, and infectious diseases in Yemen. We also performed HLA oligotyping of DRB1, DQA1, and DQB1 genes in 120 unrelated Yemenite Jews, including 44 type 1 diabetic patients and 76 healthy control subjects, and used these data in correspondence analysis comparing Yemenites with different Israeli ethnic groups. Interviews indicated that early exposure to cow's milk was very common in Yemen. However, none of the women could recall classical presentations of diabetes. HLA oligotyping showed that gene frequencies of non-Asp-57 (of the HLA-DQB chain) in the patients (0.94) and control subjects (0.6) were similar to those of other populations with a known high incidence of type 1 diabetes. Correspondence analysis revealed tha...Continue Reading

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Citations

Feb 10, 2010·International Journal of Diabetes in Developing Countries·Oindrila RahaV R Rao
Mar 15, 2005·Journal of Endocrinological Investigation·F CadarioUNKNOWN Diabetes Study Group of the Italian Society for Pediatric Endocrinology and Diabetology
Sep 26, 2002·European Journal of Pediatrics·Jacob P Van WouweRemy A HiraSing
May 1, 2010·Nature·Jeffrey A BluestoneGeorge Eisenbarth

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