Type 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment

Journal of Leukocyte Biology
Chie Hotta-Iwamura, Kristin V Tarbell

Abstract

Type 1 diabetes is an autoimmune disease that results from the defective induction or maintenance of T cell tolerance against islet β cell self-antigens. Under steady-state conditions, dendritic cells with tolerogenic properties are critical for peripheral immune tolerance. Tolerogenic dendritic cells can induce T cell anergy and deletion and, in some contexts, induce or expand regulatory T cells. Dendritic cells contribute to both immunomodulatory effects and triggering of pathogenesis in type 1 diabetes. This immune equilibrium is affected by both genetic and environmental factors that contribute to the development of type 1 diabetes. Genome-wide association studies and disease association studies have identified >50 polymorphic loci that lend susceptibility or resistance to insulin-dependent diabetes mellitus. In parallel, diabetes susceptibility regions known as insulin-dependent diabetes loci have been identified in the nonobese diabetic mouse, a model for human type 1 diabetes, providing a better understanding of potential immunomodulatory factors in type 1 diabetes risk. Most genetic candidates have annotated immune cell functions, but the focus has been on changes to T and B cells. However, it is likely that some of the...Continue Reading

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Citations

Mar 8, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cindy AudigerSylvie Lesage
Jun 15, 2017·BioMedicine·Jai-Sing YangFuu-Jen Tsai
Feb 3, 2018·Journal of Leukocyte Biology·Kristin V Tarbell, Jackson G Egen
Nov 18, 2018·F1000Research·William D ColeyKristin V Tarbell
Feb 15, 2018·Journal of Autoimmunity·Chie Hotta-IwamuraKristin V Tarbell
May 18, 2021·World Journal of Diabetes·William de Jesús Ríos-RíosHonorio Torres-Aguilar
Aug 8, 2021·International Journal of Molecular Sciences·Mohammed Yusuf ZannaMd Isa Nur Mahiza

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