Type 1 diabetes mellitus: Complex interplay of oxidative stress, cytokines, gastrointestinal motility and small intestinal bacterial overgrowth

European Journal of Clinical Investigation
Aastha MalikSatyavati Rana

Abstract

Oxidative stress is risk factor in progression of diabetes. It can increase cytokine production via several different mechanisms. Inflammation can affect gut neural apparatus that may lead to dysmotility which may exaggerate occurrence of bacterial overgrowth in intestine. Thus, a study was planned to understand the complex interplay of oxidative stress, inflammatory cytokines, gut motility and small intestinal bacterial overgrowth in type 1 diabetes mellitus (T1DM) patients. Seventy-five T1DM patients and 75 healthy controls were enrolled. Small intestinal bacterial overgrowth (SIBO) and orocecal transit time (OCTT) were measured using noninvasive glucose and lactulose hydrogen breath tests, respectively. Plasma levels of interleukin-6 (IL-6), tissue necrosis factor-alfa (TNF-α) and interleukin-10 (IL-10) were measured in all subjects by ELISA. Oxidative stress and anti-oxidant parameters were measured by standard methods. Out of 75 T1DM patients, 36 were males with Mean ± SD age 22.3 ± 5.2 years, IL-6, TNF-α and IL-10 were significantly higher (P < 0.05) in T1DM patients as compared to controls. Lipid peroxidation (LPO) was significantly increased (P < 0.001), while reduced glutathione (GSH) significantly decreased (P < 0.01)...Continue Reading

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Citations

Jan 9, 2020·Current Pharmaceutical Design·Othmar MoserPeter Hofmann
Apr 2, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Dragana KacarevicJelena Vekic
Jun 6, 2020·Current Gastroenterology Reports·Lawrence R Schiller
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Feb 6, 2020·European Journal of Clinical Investigation·Amedeo TirandiFederico Carbone
Nov 2, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Fulya ErendorSalih Sanlioglu
Jan 15, 2021·Tissue & Cell·Valéria Milena Dantas de CastroNaisandra Bezerra da Silva Farias
Nov 7, 2020·International Journal of Molecular Sciences·Agnieszka Kilanowska, Agnieszka Ziółkowska
Mar 27, 2021·Frontiers in Cellular and Infection Microbiology·Xue-Rui ShiSheng-Zhong Duan
Dec 30, 2021·Journal of Biochemical and Molecular Toxicology·Shivani SinglaGopabandhu Jena

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