Type 1 diabetes mellitus, familial hypercholesterolemia, and elevated lipoprotein (a)

Proceedings
Luke HamiltonDon Wilson

Abstract

Risk factor screening of all youth, including those with high-risk medical conditions such as diabetes mellitus, is important to reduce premature morbidity and mortality attributable to atherosclerotic cardiovascular disease. In those found to have significant hypercholesterolemia and/or elevated levels of lipoprotein (a), reverse cascade screening (child to parent) is recommended. This case demonstrates the benefits of targeted lipid testing. Early detection may provide additional motivation for families to adopt healthier lifestyles and reduce future atherosclerotic cardiovascular disease events in the child, siblings, and parents.

References

Feb 1, 1992·Atherosclerosis·N RifaiK Doetsch
Jul 1, 1992·The Journal of Clinical Investigation·E BoerwinkleH H Hobbs
Jan 29, 2002·Diabetes·Mikko J JärvisaloOlli T Raitakari
Oct 14, 2004·The Journal of Pediatrics·Jody S KrantzFrancine R Kaufman
Nov 16, 2011·Pediatrics·UNKNOWN Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents, UNKNOWN National Heart, Lung, and Blood Institute
Apr 7, 2016·Journal of the American College of Cardiology·Amit V KheraSekar Kathiresan
Aug 4, 2018·Journal of the American College of Cardiology·Amy C SturmUNKNOWN Convened by the Familial Hypercholesterolemia Foundation
Dec 1, 2019·Journal of Clinical Medicine·Natalie C WardGerald F Watts

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