Type 1 ribotoxin-curcin conjugated biogenic gold nanoparticles for a multimodal therapeutic approach towards brain cancer

Biochimica Et Biophysica Acta
M Sheikh MohamedD Sakthi Kumar

Abstract

Gliomas have been termed recurrent cancers due to their highly aggressive nature. Their tendency to infiltrate and metastasize has posed significant roadblocks to in attaining fool proof treatment solutions. An initiative to curb such a scenario was successfully demonstrated in vitro, utilizing a multi-conceptual gold nanoparticle based photo-thermal and drug combination therapy. Gold nanoparticles (Au NPs) were synthesized with a highly environmentally benign process. The Au NPs were PEGylated and conjugated with folate and transferrin antibody to achieve a dual targeted nano-formulation directed towards gliomas. Curcin, a type 1 ribosome inactivating protein, was attached to the Au NPs as the drug candidate, and its multifarious toxic aspects analyzed in vitro. NIR photo-thermal properties of the Au nano-conjugates were studied to selectively ablate the glioma cancer colonies. Highly cyto-compatible, 10-15nm Au NP conjugates were synthesized with pronounced specificity towards gliomas. Curcin was successfully conjugated to the Au NPs with pH responsive drug release. Prominent toxic aspects of curcin, such as ROS generation, mitochondrial and cytoskeletal destabilization were witnessed. Excellent photo-thermal ablation propert...Continue Reading

References

Mar 5, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maurizio BrigottiSimonetta Sperti
Feb 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Martin HrubýKarel Ulbrich
Mar 5, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S Moein MoghimiJ Clifford Murray
Feb 9, 2007·Nature Biotechnology·Roger Stupp, Monika E Hegi
Mar 29, 2007·International Journal of Cancer. Journal International Du Cancer·Yiyao LiuMichihiro Nakamura
Aug 25, 2007·Nanomedicine·Gang HanVincent M Rotello
Aug 28, 2007·Journal of the American Chemical Society·Jacob D GibsonEugene R Zubarev
Feb 12, 2008·Colloids and Surfaces. B, Biointerfaces·Robert C TriulziQun Huo
Jun 17, 2008·Advanced Drug Delivery Reviews·Partha GhoshVincent M Rotello
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wei LuChun Li
May 30, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Genevieve M FentKattesh Katti
Mar 12, 2010·Fish & Shellfish Immunology·Mariola A DietrichAndrzej Ciereszko
Dec 3, 2010·Journal of Nanoscience and Nanotechnology·Surya Singh
Jul 27, 2011·Therapeutic Advances in Medical Oncology·Nooshin Hashemi-Sadraei, David M Peereboom
Jan 10, 2012·Journal of Fluorescence·Aby Cheruvathoor PouloseD Sakthi Kumar
Feb 15, 2012·Advanced Drug Delivery Reviews·Min Suk Shim, Young Jik Kwon
Jun 5, 2012·ACS Nano·Stefaan J SoenenKevin Braeckmans
Jul 12, 2012·Chemical Communications : Chem Comm·Zhefan YuanFeng Li

❮ Previous
Next ❯

Citations

Oct 6, 2015·Advanced Drug Delivery Reviews·Harutaka MekaruFuyuhiko Tamanoi
Feb 24, 2015·Bioscience, Biotechnology, and Biochemistry·Lidia Patricia Jaramillo-QuinteroAlma Leticia Martínez-Ayala
Oct 25, 2016·Scientific Reports·Aby Cheruvathoor PouloseD Sakthi Kumar
Aug 20, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Srishti AgarwalD Sakthi Kumar
Jul 17, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Georgios P SkandalakisConstantinos G Hadjipanayis
Oct 31, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Narintorn RattanataJureerut Daduang
Mar 3, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Emilie DarriguesAnaliz Rodriguez
Nov 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Srivani VeeranarayananD Sakthi Kumar
Oct 23, 2020·Chemical Society Reviews·Zoë Rachael GoddardMark Searcey
Apr 18, 2014·Molecular Pharmaceutics·Haiming LuoWeibo Cai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Cell Invasion: Nanomedicine

Nanomedicine is a promising alternative for cancer detection and therapy that utilizes nanoparticles, such as liposomes. Nanoparticles can potentially target cancer cell invasion and metastasis. Discover the latest research on Cancer Cell Invasion: Nanomedicine here.

© 2021 Meta ULC. All rights reserved