Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum

Journal of Neurochemistry
Akira FutatsugiK Mikoshiba

Abstract

During postnatal development of the cerebellum, granule cell precursors (GCPs) proliferate in the external granular layer (EGL), exit the cell cycle, differentiate, and migrate from the EGL to the internal granular layer. In the present study, we report that type 2 and 3 inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)R2 and IP(3)R3) regulate the differentiation of GCPs after postnatal day 12 (P12). 5-Bromodeoxyuridine labeling experiments revealed that in mutant mice lacking both of these receptors (double mutants) a greater number of GCPs remain undifferentiated after P12. Consequently, the EGL of the double mutants is thicker than that of control mice at this age and thereafter. In addition, granule cells remain in the EGL of the double mutants at P21, an age when migration has concluded in wild-type mice. Whereas differentiation of GCPs was reduced in the double mutants, the absence of IP(3)R2 and IP(3)R3 did not affect the doubling time of GCPs. We conclude that intracellular calcium release via IP(3)R2s and IP(3)R3s promotes the differentiation of GCPs within a specific interval of postnatal development in the cerebellum.

References

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May 20, 2005·Nature·Vanessa DepaepePierre Vanderhaeghen
Oct 1, 2005·Science·Akira FutatsugiKatsuhiko Mikoshiba
Nov 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yoojin ChoiRosalind A Segal
Apr 6, 2006·The Journal of Biological Chemistry·Eugen BrailoiuNae J Dun
Oct 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chihiro HisatsuneKatsuhiko Mikoshiba
Mar 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tetsushi SadakataTeiichi Furuichi

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Citations

Sep 17, 2009·Immunological Reviews·Takako Negishi-Koga, Hiroshi Takayanagi
Aug 8, 2020·British Journal of Pharmacology·Mireia Herrando-GrabulosaXavier Navarro
Jan 16, 2021·Scientific Reports·Lilla E SzabóBence Rácz

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