Type 2 deiodinase Thr92Ala polymorphism is associated with disrupted placental activity but not with dysglycemia or adverse gestational outcomes: a genetic association study

Fertility and Sterility
José M DoraAna Luiza Maia

Abstract

To study whether the D2 Thr92Ala polymorphism-a genetic marker that is associated with reduced thyroid type 2 deiodinase (D2) activity, increased insulin resistance, and risk for type 2 diabetes-is associated with disrupted placental D2 activity and with glycemic control and gestational outcomes. Cross-sectional study. Tertiary hospital in Brazil. Consecutive singleton-pregnancy patients, 18-45 years old. Clinical examination and genotyping of the D2 Thr92Ala polymorphism, with placental samples collected and assayed for D2 mRNA and activity. Glucose homeostasis and gestational outcomes. A total of 294 patients were included in the study. The clinical and laboratory characteristics were similar among the D2 genotypes. No differences were observed in D2 placental mRNA levels, but D2 activity was decreased in patients with the Ala92Ala genotype (0.35 ± 0.15 vs. 1.96 ± 1.02 fmol/mg/min.). Newborn serum thyroid-stimulating hormone levels (TSHneo) did not differ according to maternal D2 Thr92Ala genotype. Also, maternal glucose control, insulin resistance evaluated by the homeostasis model assessment (HOMA-IR), and gestational outcomes did not differ across D2 genotypes. The D2 Ala92Ala genotype is associated with reduced placental ...Continue Reading

References

Oct 20, 1994·The New England Journal of Medicine·G N BurrowP R Larsen
Aug 19, 1999·The New England Journal of Medicine·J E HaddowR Z Klein
Jan 5, 2000·The New England Journal of Medicine·C Herzmann, J K Torrens
Sep 10, 2003·Endocrinology·Emily C WascoValerie Anne Galton
Aug 30, 2005·The Journal of Clinical Investigation·Ana Luiza MaiaP Reed Larsen
Nov 12, 2005·Bioscience Reports·Antonio C BiancoMarcelo A Christoffolete
Jan 18, 2006·The Journal of Clinical Investigation·Arturo HernandezDonald St Germain
Jan 17, 2007·Hypertension·Olga GumieniakGordon H Williams
Mar 13, 2008·Human Molecular Genetics·Ingrid MeulenbeltP Eline Slagboom
Mar 19, 2009·The Journal of Clinical Endocrinology and Metabolism·Karen A HeemstraTheo J Visser
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Karen A HeemstraJohannes W Smit
Jun 23, 2010·European Journal of Endocrinology·José Miguel DoraAna Luiza Maia

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Citations

Jul 21, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Peter N TaylorColin M Dayan
Nov 5, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Lucia Maria ProcopciucFlorin Stamatian

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