Type 2 diabetes and cardiac autonomic neuropathy screening using dynamic pupillometry

Diabetic Medicine : a Journal of the British Diabetic Association
A G LernerCRONICAS Cohort Study Group

Abstract

To determine if changes in pupillary response are useful as a screening tool for diabetes and to assess whether pupillometry is associated with cardiac autonomic neuropathy. We conducted a cross-sectional study with participants drawn from two settings: a hospital and a community site. At the community site, individuals with newly diagnosed diabetes as well as a random sample of control individuals without diabetes, confirmed by oral glucose tolerance test, were selected. Participants underwent an LED light stimulus test and eight pupillometry variables were measured. Outcomes were diabetes, defined by oral glucose tolerance test, and cardiac autonomic dysfunction, determined by a positive readout on two of four diagnostic tests: heart rate response to the Valsalva manoeuvre; orthostatic hypotension; 30:15 ratio; and expiration-to-inspiration ratio. The area under the curve, best threshold, sensitivity and specificity of each pupillometry variable was calculated. Data from 384 people, 213 with diabetes, were analysed. The mean (±sd) age of the people with diabetes was 58.6 (±8.2) years and in the control subjects it was 56.1 (±8.6) years. When comparing individuals with and without diabetes, the amplitude of the pupil reaction ...Continue Reading

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Citations

Apr 25, 2016·Annals of Global Health·Jaime E Villena
Nov 26, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·T StewartW Checkley
Sep 11, 2019·Eye & Contact Lens·Hasan KiziltoprakKemal Ozulken
Oct 6, 2020·Neuro-ophthalmology·Hasan KızıltoprakPelin Yilmazbas
Mar 12, 2019·Frontiers in Neurology·Carina KelbschBarbara J Wilhelm
Dec 29, 2020·Primary Care Diabetes·Jorge R Calderon-TiconaMaria Lazo-Porras
Apr 8, 2021·Journal of Biomedical Informatics·Hedenir Monteiro Pinheiro, Ronaldo Martins da Costa
Oct 7, 2021·International Ophthalmology·Serap Yurttaser OcakEmine Bas

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