Type 2 diabetes and risk of hospital admission or death for chronic liver diseases

Journal of Hepatology
S H WildScottish Diabetes Research Network Epidemiology Group

Abstract

The impact of type 2 diabetes (T2DM) on hospital admissions and deaths due to common chronic liver diseases (CLDs) is uncertain. Our aim was to investigate associations between T2DM and CLDs in a national retrospective cohort study and to investigate the role of sex and socio-economic status (SES). We used International Classification of Disease codes to identify incident alcoholic liver disease (ALD), autoimmune liver disease, haemochromatosis, hepatocellular carcinoma, non-alcoholic fatty liver disease (NAFLD) and viral liver disease from linked diabetes, hospital, cancer and death records for people of 40-89years of age in Scotland 2004-2013. We used quasi Poisson regression to estimate rate ratios (RR). There were 6667 and 33624 first mentions of CLD in hospital, cancer and death records over ∼1.8 and 24million person-years in people with and without T2DM, respectively. The most common liver disease was ALD among people without diabetes and was NAFLD among people with T2DM. Age-adjusted RR for T2DM compared to the non-diabetic population (95% confidence intervals) varied between 1.27 (1.04-1.55) for autoimmune liver disease and 5.36 (4.41-6.51) for NAFLD. RRs were lower for men than women and for more compared to less depri...Continue Reading

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Citations

Feb 28, 2016·Journal of Hepatology·Vincent Wai-Sun Wong, Naga Chalasani
Mar 25, 2016·Digestive Diseases and Sciences·Raj Vuppalanchi, Naga Chalasani
Jan 24, 2018·Diabetes Care·Alessandro MantovaniGiovanni Targher
Mar 24, 2016·International Journal of Molecular Sciences·Stefano BallestriAmedeo Lonardo
Oct 5, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Richard A Burkhart, Timothy M Pawlik
Dec 30, 2017·Nature Reviews. Endocrinology·Giovanni TargherChristopher D Byrne
May 18, 2020·Clinical Medicine : Journal of the Royal College of Physicians of London·Ahmed HussainWilliam Rosenberg
Oct 19, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Yi ShenFeng Liang
Apr 4, 2021·Journal of Clinical Medicine·Raluca Pais, Thomas Maurel
Aug 17, 2020·European Journal of Gastroenterology & Hepatology·Karl BjörkströmHannes Hagström

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