Type 2 Diabetes Mellitus and Heart Failure: A Scientific Statement From the American Heart Association and the Heart Failure Society of America

Circulation
Shannon M DunlayAmerican Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology; Council on Car

Abstract

Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of morbidity and mortality in patients with established disease. Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden of disease and underscore the need for effective therapeutic strategies. Recent clinical trials have demonstrated the shared pathophysiology between diabetes mellitus and heart failure, the synergistic effect of managing both conditions, and the potential for diabetes mellitus therapies to modulate the risk of heart failure outcomes. This scientific statement on diabetes mellitus and heart failure summarizes the epidemiology, pathophysiology, and impact of diabetes mellitus and its control on outcomes in heart failure; reviews the approach to pharmacological therapy and lifestyle modification in patients with diabetes mellitus and heart failure; highlights the value of multidisciplinary interventions to improve clinical outcomes in this population; and outlines priorities for future research.

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Apr 4, 2020·Diabetes, Obesity & Metabolism·Javed ButlerJulio Rosenstock
May 12, 2020·Journal of Medicinal Food·Jung Hyun KwakJean Kyung Paik
Apr 20, 2020·European Journal of Clinical Investigation·Sebastian CarballoDavid Carballo
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Apr 10, 2021·Current Heart Failure Reports·Christine ChowStephen J Greene

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