Type 2 diabetes mellitus coincident with pulmonary or latent tuberculosis results in modulation of adipocytokines

Cytokine
Nathella Pavan KumarSubash Babu

Abstract

Type 2 diabetes mellitus (T2DM) is recognized as major risk factor for the progress of active pulmonary tuberculosis (PTB), although the mechanistic link between diabetes and tuberculosis remains poorly characterized. Moreover, the influence of poorly controlled diabetes on the baseline levels of adipocytokines in the context of tuberculosis has not been explored in detail. To characterize the influence of coexistent DM on adipocytokine levels in pulmonary or latent TB (LTB), we examined circulating levels of adipocytokines in the plasma of individuals with PTB-DM or LTB-DM and compared them with those without DM (PTB or LTB). PTB-DM or LTB-DM is characterized by diminished circulating levels of adiponectin and adipsin and/or heightened circulating levels of leptin, visfatin and PAI-1. In addition, adiponectin and adipsin exhibit a significant negative correlation, whereas leptin, visfatin and PAI-1 display a significant positive correlation with HbA1C levels and random blood glucose levels. Therefore, our data reveal that PTB-DM or LTB-DM is characterized by alterations in the systemic levels of adipocytokines, indicating that altered adipose tissue inflammation underlying Type 2 diabetes potentially contributes to pathogenesi...Continue Reading

References

Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y XuJ E Volanakis
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Reinout van CrevelJos W M van der Meer
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Anastassios G PittasAndrew S Greenberg
May 4, 2004·Nature Reviews. Immunology·Antonio La Cava, Giuseppe Matarese
Aug 3, 2004·Nature Reviews. Cancer·Eugenia E Calle, Rudolf Kaaks
Sep 29, 2004·Diabetes Care·Wolfgang Rathmann, Guido Giani
May 3, 2005·The Journal of Clinical Investigation·Kathryn E Wellen, Gökhan S Hotamisligil
Aug 18, 2005·Clinical Science·Christine M KusminskiSudhesh Kumar
Dec 13, 2005·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Jul 11, 2006·The Journal of Clinical Investigation·Takashi KadowakiKazuyuki Tobe
Sep 26, 2006·Nature Reviews. Immunology·Herbert Tilg, Alexander R Moschen
Mar 31, 2007·Drug Discovery Today·Adelino F Leite-Moreira, João-Bruno Soares
May 15, 2007·Mediators of Inflammation·Hakan BuyukoglanMustafa Ozesmi
Aug 25, 2007·The Journal of Clinical Investigation·Ja-Young KimPhilipp E Scherer
Sep 26, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Petra WiedmerMatthias H Tschöp
Apr 11, 2008·American Journal of Epidemiology·Chi C LeungKwok C Chang
Nov 21, 2009·The Lancet Infectious Diseases·Kelly E Dooley, Richard E Chaisson
Feb 16, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ji Hae KimJae Ho Lee
May 19, 2011·Critical Care : the Official Journal of the Critical Care Forum·Katherine RobinsonBala Venkatesh
Jul 5, 2011·BMC Medicine·Meghan A BakerMegan B Murray
Nov 30, 2011·Diabetologia·J M Fernández-Real, J C Pickup
Jul 6, 2014·Cell·James C LoBruce M Spiegelman

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Citations

May 10, 2017·Future Microbiology·Haipeng Liu, Baoxue Ge
May 26, 2017·Immunology·Pavan Kumar Nathella, Subash Babu
Jul 26, 2018·Biomarkers in Medicine·Mariana Salgado-BustamanteYamilé López-Hernández
Jun 18, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Gebrehiwot Gebremedhin TafereMuluken Altaye Ayza
Jan 8, 2021·International Journal of Environmental Research and Public Health·Phan Ai PingHarmy Mohamed Yusoff

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