Type 2 Diabetes Mellitus: Integrative Analysis of Multiomics Data for Biomarker Discovery

Omics : a Journal of Integrative Biology
Siqi GeWei Wang

Abstract

Increased fasting plasma glucose (FPG) is an independent risk factor for type 2 diabetes mellitus (T2DM). The development of systems biology technologies for integration of multiomics data is crucial for predicting increased FPG levels. In this case-control study, immunoglobulin (Ig) G glycosylation profiling and genome-wide association analyses were performed on 511 participants, and among them 76 had increased FPG (aged 47.6 ± 6.14 years), and 435 had decreased or fluctuant FPG (aged 47.9 ± 6.08 years). We identified nine single nucleotide polymorphisms (SNPs) in five genes (RPL7AP27, SNX30, SLC39A12, BACE2, and IGFL2) that were significantly associated with increased FPG (odds ratios 1.937-2.393). Moreover, of the 24 glycan peaks (GPs), GPs 3, 8, and 11 presented positive trends with increased FPG levels, whereas GPs 4 and 14 presented negative trends. A significant improvement of predictive power was observed when adding 24 IgG GPs to 9 SNPs with the area under the curve increased from 0.75 to 0.81. This report shows that the combination of candidate SNPs with IgG glycomics offers biomarker potentials for T2DM. The substantial predictive power obtained from integrating genomics and glycomics biomarkers suggests the feasibil...Continue Reading

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Citations

Nov 21, 2018·Omics : a Journal of Integrative Biology·Qingwei MaWei Wang
Oct 28, 2019·Omics : a Journal of Integrative Biology·Wei Wang
Jan 7, 2021·Omics : a Journal of Integrative Biology·Medi KoriKazim Yalcin Arga
Feb 6, 2021·Npj Aging and Mechanisms of Disease·Xiaoyu ZhangYouxin Wang
Jan 26, 2021·Journal of Diabetes·Zhiyuan WuXiuhua Guo
Apr 4, 2021·International Journal of Molecular Sciences·Gratiela Gradisteanu PircalabioruOctavian Savu
Jun 3, 2021·International Journal of Molecular Sciences·Beatrix PatonNúria Canela
Jul 31, 2021·World Journal of Diabetes·Shuai WangXiao-Dong He
Jul 13, 2021·Gene·Danielle N DavisWinyoo Chowanadisai
Aug 18, 2021·Endocrinology and Metabolism Clinics of North America·Chang Liu, Yan V Sun

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Methods Mentioned

BETA
glycosylation
genotyping
chips

Software Mentioned

gplots
SPSS
GenABEL
R

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