Type 2 diabetes mellitus is associated with differential effects on plasma cholesteryl ester transfer protein and phospholipid transfer protein activities and concentrations

Scandinavian Journal of Clinical and Laboratory Investigation
R P DullaartA Van Tol

Abstract

Human plasma contains two lipid transfer proteins, cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP), which are crucial in reverse cholesterol transport. Plasma CETP and PLTP activity levels and concentrations in 16 type 2 diabetic patients and 16 matched healthy subjects were determined, and these data were correlated to clinical variables, including insulin sensitivity and lipid levels. Plasma triglycerides were higher (p<0.02) and high-density lipoprotein (HDL) cholesterol (p<0.02) was lower in diabetic patients. Plasma CETP activity and concentrations were not significantly different between diabetic and healthy subjects, but CETP specific activity was lower in diabetic patients (p<0.001). Multiple regression analysis showed that plasma CETP activity was positively related to CETP concentration (p=0.0001) and negatively to the diabetic state (p<0.002) or to HbA1c (p<0.02). PLTP activity (p<0.05) and specific activity were higher (p<0.05), whereas there was no difference in PLTP concentration between the two groups. There was no significant bivariate correlation between PLTP concentration and activity, in either healthy or diabetic subjects. Multiple regression analysis did disclose positive ...Continue Reading

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Citations

May 18, 2013·Diabetes & Metabolic Syndrome·Md N KarimLiaquat Ali
Jul 9, 2011·Biochimica Et Biophysica Acta·John J AlbersMarian C Cheung
Mar 24, 2009·Biochimica Et Biophysica Acta·G M Dallinga-ThieUNKNOWN Diabetes Atorvastatin lipid intervention (DALI) study group
Nov 18, 2014·European Journal of Clinical Investigation·Robin P F DullaartGeesje M Dallinga-Thie
Feb 22, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Ulrich JuliusJens Pietzsch
Feb 21, 2009·Nature Clinical Practice. Endocrinology & Metabolism·Arshag D Mooradian
Apr 24, 2018·Journal of the American Heart Association·Yang YuXian-Cheng Jiang
Aug 22, 2007·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Y InukaiT Inukai
Apr 5, 2008·Obesity·Arshag D MooradianNorman C W Wong
Jun 1, 2019·Future Cardiology·Lesly-Anne SamedyKathryn M Momary
Mar 7, 2015·Journal of the American Society of Nephrology : JASN·Michael HolzerGunther Marsche
Jan 27, 2021·Current Atherosclerosis Reports·Xian-Cheng Jiang, Yang Yu
Jul 6, 2021·Frontiers in Cardiovascular Medicine·Qiuzhen LinLing Liu

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