Abstract
Diabetic neuropathy is a chronic and often disabling condition that affects a significant number of individuals with diabetes mellitus (DM). It is now established that DM causes various CNS complications like Alzheimer's, dementia, anxiety, depression, neurodegeneration, mood disorders, cognitive dysfunctioning, and so on. Since amygdala and dopaminergic circuitry are critical in controlling several aspects of social behavior, even social recognition memory (SRM), we aimed to study the expression analysis of dopaminergic circuitry in amygdala using real-time polymerase chain reaction. Animals were divided into 2 age- and weight-matched groups: group I-control group and group II-diabetic group. Diabetes was induced by injecting 50 mg/kg streptozotocin (STZ; in 0.1 mL ice cold citrate buffer, pH 4.5) i.p. for 5 consecutive days. Behavioral tests were performed 8 weeks after diabetes was introduced. On day 60, animals were sacrificed, amygdala was dissected, and the total RNA was isolated. Expression analysis was carried out using real time PCR. No significant changes were observed in social interaction and social isolation aspects of diabetic mice, but SRM was significantly dysregulated. Additionally, we found that dopaminergic n...Continue Reading
References
Oct 6, 1983·Nature·G P Reynolds
Nov 1, 1996·Diabetologia·A OttM M Breteler
Feb 15, 1997·American Journal of Epidemiology·C L LeibsonP J Palumbo
Nov 21, 1997·BMJ : British Medical Journal·J KuusistoM Laakso
Apr 2, 1999·Neurology·J D CurbL R White
Nov 25, 2000·Metabolism: Clinical and Experimental·M J ReedG M Reaven
Dec 6, 2000·Progress in Brain Research·J A ParkinsonB J Everitt
Oct 3, 2001·American Journal of Epidemiology·J A LuchsingerR Mayeux
Mar 28, 2002·Diabetes·Rita PeilaUNKNOWN Honolulu-Asia Aging Study
Sep 18, 2004·Peptides·Isadora F Bielsky, Larry J Young
Jun 28, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K SrinivasanP Ramarao
Oct 26, 2005·Neuron·Elizabeth A Phelps, Joseph E LeDoux
Nov 12, 2005·Diabetologia·T CukiermanJ D Williamson
May 24, 2007·Schizophrenia Bulletin·Steven R Laviolette
Apr 26, 2008·Endocrine Reviews·Christopher T Kodl, Elizabeth R Seaquist
Jun 14, 2008·Biological Psychiatry·Kevin N Ochsner
Sep 4, 2008·Neurology·M S BeeriV Haroutunian
Mar 24, 2010·Schizophrenia Bulletin·Andrew J RosenfeldL Fredrik Jarskog
Jun 19, 2010·CNS Neuroscience & Therapeutics·Tracey A Baskerville, Alison J Douglas
Jun 15, 2011·Current Diabetes Reports·Dinesh SelvarajahSolomon Tesfaye
Jul 7, 2011·Current Protocols in Neuroscience·Mu YangJacqueline N Crawley
Dec 1, 1994·Behavioural Processes·G GheusiR Dantzer
Nov 27, 2015·BMC Neuroscience·Sara A KarlssonLars Westberg
Dec 5, 2015·Frontiers in Endocrinology·Ewan McNay
Citations
Nov 21, 2019·Molecular Medicine Reports·Yang JiaoYonghao Yu
Aug 21, 2020·Molecular Neurobiology·Lin WangXin-Wen Zhou
Nov 16, 2018·Frontiers in Neurology·Young-Kook KimJuhyun Song
Jun 11, 2020·Molecular Neurobiology·Lin WangXin-Wen Zhou
Jul 1, 2020·Brain Research Bulletin·Yun CaoXinwen Zhou
Jan 21, 2021·International Journal of Molecular Sciences·So Yeong Cheon, Juhyun Song
Dec 10, 2020·Molecular Therapy. Nucleic Acids·Xue-Feng LiShao-Nan Yu
Feb 3, 2021·The European Journal of Neuroscience·Rhea SubbaAmal Chandra Mondal